Semialactone
Semialactone shows inhibitory activities on human acyl-CoA:cholesterol acyltransferase(hACAT)1 with IC50 values of 79.1 uM and on human hACAT2 with IC50 values of 76.9 uM, it may be effective in the prevention and treatment of hypercholesterolemia or atherosclerosis via inhibitory effect on hACAT.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Appl. Biol.Chem.,2010, 53(4):417-21.
Human Acyl-CoA:Cholesterol Acyltransferase-inhibiting Dammarane Triterpenes from Rhus chinensis[Reference:
WebLink]
METHODS AND RESULTS:
In the process of screening for anti-human acyl-CoA:cholesterol acyltransferase (hACAT) agents from plant resources, we found that the 80% methanolic extract of Rhus chinensis (R. chinensis) exhibited significant antioxidative and hACAT activities in rats. Two compounds were isolated as active principles from the ethyl acetate soluble fraction of the branches of R. chinensis. The structures of compounds 1 and 2 were determined as hydroxydammarenone and Semialactone, respectively, by means of MS and NMR spectroscopic analysis. Compound 1 has been isolated from this plant for the first time. Compounds 1 and 2 showed inhibitory activities on both human ACAT1 with IC50 values of 12.4, and 79.1 μM and on human ACAT2 with IC50 values of 30.5 and 76.9 μM, respectively.
CONCLUSIONS:
These results suggested that R. chinensis containing dammarane triterpenes 1 and 2 might be effective in the prevention and treatment of hypercholesterolemia or atherosclerosis via inhibitory effect on hACAT.
Chem Pharm Bull (Tokyo). 2001 Aug;49(8):1024-6.
Semialactone, isofouquierone peroxide and fouquierone, three new dammarane triterpenes from Rhus javanica.[Pubmed:
11515571]
METHODS AND RESULTS:
Three new dammarane triterpenes and semialactic acid were isolated from the stem bark of Rhus javanica.
The structures of these triterpenes, named Semialactone, isofouquierone peroxide and fouquierone, were elucidated by 2D-NMR analysis (HMQC, 1H-1H COSY and HMBC), and the 13C-NMR data of semialatic acid is revised.
