S-Adenosyl-L-methionine tosylate
S-adenosyl-L-methionine tosylate has a beneficial effect on the outcome of ischemic injury by reducing the blood-brain barrier (BBB) breakdown and neuronal death.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Nutrients.2023, 15(6):1335.
J of Archaeological Science:Reports2024, 53:104298
Cells.2022, 11(6):931.
Korean J. of Horticultural Sci. & Tech. 2017, 793-804
Applied Biological Chemistry2021, 64(4)
Journal of Third Military Medical University2019, 41(2):110-115
PLoS One.2017, 12(8):e0181191
Biochem Pharmacol. 2020, 177:114014.
Evid Based Complement Alternat Med.2018, 2018:4259603
Molecules.2023, 28(2):727.
Related and Featured Products
Brain Res Mol Brain Res. 1997 Feb;44(1):134-8.
Beneficial effects of S-adenosyl-L-methionine on blood-brain barrier breakdown and neuronal survival after transient cerebral ischemia in gerbils.[Pubmed:
9030707]
We have studied the beneficial effects of S-Adenosyl-L-methionine tosylate on blood-brain barrier (BBB) breakdown and neuronal survival after transient cerebral ischemia in gerbils.
METHODS AND RESULTS:
BBB breakdown experiments were performed in pentobarbital anesthetized gerbils subjected to 10 min of bilateral carotid artery occlusion and 6 h of reperfusion. For BBB breakdown measurements, S-adenosyl-L-methionine (120 mg/kg, i.p.) was administered to gerbils just after occlusion and thereafter every hour up to 5 h. Fluorometric measurements quantified the blood-brain permeability tracer, Evans blue (EB). S-adenosyl-L-methionine treatment significantly reduced the BBB breakdown as indicated by reduced levels of EB fluorescence. Neuronal count experiments were conducted in gerbils subjected to transient ischemia and 7 days of reperfusion. For neuronal count experiments S-adenosyl-L-methionine (15-120 mg/kg) was administered at 6 and 12 h after reperfusion, and twice each day thereafter for 7 days. S-adenosyl-L-methionine dose dependently protected the hippocampal CA1 neurons assessed by histopathological methods.
CONCLUSIONS:
S-adenosyl-L-methionine has a beneficial effect on the outcome of ischemic injury by reducing the BBB breakdown and neuronal death.
