S-Adenosyl-L-methionine tosylate
S-adenosyl-L-methionine tosylate has a beneficial effect on the outcome of ischemic injury by reducing the blood-brain barrier (BBB) breakdown and neuronal death.
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Beneficial effects of S-adenosyl-L-methionine on blood-brain barrier breakdown and neuronal survival after transient cerebral ischemia in gerbils.[Pubmed:
9030707]
We have studied the beneficial effects of S-Adenosyl-L-methionine tosylate on blood-brain barrier (BBB) breakdown and neuronal survival after transient cerebral ischemia in gerbils.
METHODS AND RESULTS:
BBB breakdown experiments were performed in pentobarbital anesthetized gerbils subjected to 10 min of bilateral carotid artery occlusion and 6 h of reperfusion. For BBB breakdown measurements, S-adenosyl-L-methionine (120 mg/kg, i.p.) was administered to gerbils just after occlusion and thereafter every hour up to 5 h. Fluorometric measurements quantified the blood-brain permeability tracer, Evans blue (EB). S-adenosyl-L-methionine treatment significantly reduced the BBB breakdown as indicated by reduced levels of EB fluorescence. Neuronal count experiments were conducted in gerbils subjected to transient ischemia and 7 days of reperfusion. For neuronal count experiments S-adenosyl-L-methionine (15-120 mg/kg) was administered at 6 and 12 h after reperfusion, and twice each day thereafter for 7 days. S-adenosyl-L-methionine dose dependently protected the hippocampal CA1 neurons assessed by histopathological methods.
CONCLUSIONS:
S-adenosyl-L-methionine has a beneficial effect on the outcome of ischemic injury by reducing the BBB breakdown and neuronal death.
