Loroquine
Reference standards.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Revista Brasileira de Farmacognosia2021, 31:794-804.
J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):21-39.
Universite de Bordeaux2017, 2017BORD0867
Pak J Pharm Sci.2019, 32(6):2879-2885
Mol Plant Pathol.2023, 24(2):123-141.
Metabolites.2020, 10(12):497.
J.Korean Society of Grassland&Forage Science2023, 43(3):138-147.
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European Journal of Organic Chemistry 1993(7):711-713.
Synthesis of 2,3Dihydro7-hydroxymethyl-1H-pyrrolizin-1-one, the Alkaloid Loroquine.[Reference:
WebLink]
METHODS AND RESULTS:
The title compound 4 is synthesized in 8 steps by cyclization of N-tosylglycinate 5 with vinyl ketone 6. After elimination of water and sulfinic acid the pyrrolecarboxylate 9 is obtained which, on N-alkylation with ethyl acrylate, Dieckmann cyclization, saponification and decarboxylation, yields methylLoroquine 12. The reaction with chlorotrimethylsilane/sulfuric acid in acetic anhydride and subsequent saponification give Loroquine (4) in 2.1% overall yield.
