Isoretronecanol

Isoretronecanol
Product Name Isoretronecanol
CAS No.: 526-63-6
Catalog No.: CFN00281
Molecular Formula: C8H15NO
Molecular Weight: 141.21 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Oil
Source:
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Standard reference
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Tetrahedron,2014,70(2):204–11.
    Asymmetric syntheses of (−)-isoretronecanol and (−)-trachelantamidine[Reference: WebLink]
    Short and concise total asymmetric syntheses of (−)-Isoretronecanol and (−)-trachelantamidine are reported.
    METHODS AND RESULTS:
    Oxidative cleavage of tert-butyl (S,S,S,Z)-7-[N-benzyl-N-(α-methylbenzyl)amino]cyclohept-3-ene-1-carboxylate, followed by hydrogenolysis promoted in situ cyclisation/reduction, which provided rapid access to the bicyclic core within (−)-Isoretronecanol. Analogous treatment of the C(1)-epimer gave (−)-trachelantamidine.
    CONCLUSIONS:
    Overall, the syntheses of (−)-Isoretronecanol and (−)-trachelantamidine were completed in eight and seven steps and 20 and 9.5% yield, respectively, from commercially available starting materials.
    Tetrahedron Letters,2005,46(15);2691-3.
    The stereoselective addition of titanium(IV) enolates of 1,3-oxazolidin-2-one and 1,3-thiazolidine-2-thione to cyclic N-acyliminium ion. The total synthesis of (+)-isoretronecanol[Reference: WebLink]

    METHODS AND RESULTS:
    (+)-Isoretronecanol (1) has been prepared in four steps and 36% overall yield via the diastereoselective addition of the titanium(IV) enolate derived from N-4-chlorobutyryl-1,3-thiazolidine-2-thione (3) to N-Boc-2-methoxypyrrolidine (5), which afforded 2-substituted pyrrolidine 7 in 84% yield (8:1 diastereoisomeric ratio), followed by reductive recovery of the chiral auxiliary and cyclization.
    Tetrahedron: Asymmetry,2011,22(6):662–668.
    A common approach to pyrrolizidine and indolizidine alkaloids; formal synthesis of (−)-isoretronecanol, (−)-trachelanthamidine and an approach to the synthesis of (−)-5-epitashiromine and (−)-tashiromine[Reference: WebLink]

    METHODS AND RESULTS:
    A common and short stereoselective route is described for the formal synthesis of pyrrolizidine alkaloids, (−)-Isoretronecanol and (−)-trachelanthamidine. An approach to the synthesis of indolizidine alkaloids (−)-5-epitashiromine and (−)-tashiromine utilizing ring closing metathesis is also described starting from commercially available and inexpensive l-proline.
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