Lobetyol

Nat Prod Res. 2008 Apr 15;22(6):477-82.

Chemical composition and antioxidant activity of Campanula alliariifolia.[Pubmed: 18415853]

In this study, the chemical constituents of Campanula alliariifolia Willd. (Campanulaceae) are being investigated for the first time with the aid of this article.
METHODS AND RESULTS:
Five known compounds, which were quercetin-3-O-glucoside, quercetin-3-O-rutinoside, kaempferol-3-O-glucoside, Lobetyolin (9-O-beta-D-glucopyranosyl-2,10-tetradecadien-4,6-diyne-8,14-diol) and Lobetyol (2,10-tetradecadien-4,6-diyne-8,9,14-triol), were isolated from the methanol extract. The antioxidant activity of the methanol extract and the purified compounds of the plant was investigated with DPPH (1,1-diphenyl-picrilyhydrazyl) (free radical scavenging activity) and reducing power methods.
CONCLUSIONS:
The methanol extract has antioxidant capacity according to the mentioned methods. Lobetyol and Lobetyolin showed significant antioxidant activity more than both methanol extract and other purified compounds.

Tuberc Respir Dis (Seoul). 2014 Nov;77(5):203-8.

Effects of Lobetyolin, Lobetyol and Methyl linoleate on Secretion, Production and Gene Expression of MUC5AC Mucin from Airway Epithelial Cells.[Pubmed: 25473407]

In this study, we investigated whether Lobetyolin, Lobetyol, and methyl linoleate derived from Codonopsis pilosula affect MUC5AC mucin secretion, production, and gene expression from airway epithelial cells.
METHODS AND RESULTS:
Confluent NCI-H292 cells were pretreated with Lobetyolin, Lobetyol, or methyl linoleate for 30 minutes and then stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 hours. The MUC5AC mucin gene expression, and mucin protein production and secretion were measured by reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay, respectively.Lobetyolin, Lobetyol, and methyl linoleate inhibited the gene expression of MUC5AC mucin induced by PMA; Lobetyolin did not affect PMA-induced MUC5AC mucin production. However, Lobetyol and methyl linoleate inhibited the production of MUC5AC mucin; Lobetyolin and Lobetyol did not significantly affect PMA-induced MUC5AC mucin secretion from NCI-H292 cells. However, methyl linoleate decreased the MUC5AC mucin secretion.
CONCLUSIONS:
These results suggest that among the three compounds, methyl linoleate can regulate gene expression, production, and secretion of MUC5AC mucin by directly acting on the airway epithelial cells.