Kushenol A

Kushenol A
Product Name Kushenol A
CAS No.: 99217-63-7
Catalog No.: CFN92000
Molecular Formula: C25H28O5
Molecular Weight: 408.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Cryst.
Targets: cAMP
Source: The roots of Sophora flavescens Ait.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $413/5mg
Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushenol A and kushenol C exhibit inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
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    Biol. Pharm. Bull., 2006, 29(2):302-5.
    Glycosidase inhibitory flavonoids from Sophora flavescens.[Pubmed: 16462036]
    The methanol extract of Sophora flavescens showed a potent glycosidase inhibitory activity.
    METHODS AND RESULTS:
    Active components were identified as well-known flavonoid antioxidants: Kushenol A (1), (-)-kurarinone (2), sophoraflavanone G (3), 2'-methoxykurarinone (4), kurarinol (5), 8-prenylkaempferol (6), isoxanthohumol (7), kuraridin (8) and maackian (9). All flavonoids were effective inhibitors of alpha-glucosidase and beta-amylase. Interestingly, lavandulylated flavanones 1-5 had strong alpha-glucosidase inhibitory activities, with IC(50) values of 45 microM, 68 microM, 37 microM, 155 microM and 179 microM, respectively. Kushenol A (1) which does not bear a 4'-hydroxy group showed selective alpha-glucosidase inhibitory activity. Lavandulylated chalcone, kuraridine (8), exhibited IC(50) value of 57 microM against beta-glucosidase, which is the first report of a chalcone displaying glycosidase inhibition.
    CONCLUSIONS:
    Results showed that 8-lavandulyl group in B-ring was a key factor of the glycosidase inhibitory activities. The inhibition pattern was noncompetitive for alpha-glucosidase, whereas mixed inhibition was observed for beta-amylase.
    Chem. Pharm. Bull., 1986, 34(5):2094-9.
    Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by components of Sophora flavescens Aiton.[Pubmed: 3017587]
    Adenosine 3', 5'-cyclic monophosphate (cAMP) phosphodiesterase inhibitiors contained in the roots of Sophora flavescens AITON were identified as flavonoids, Kushenol A (9), kurarinone (5), and kuraridin (22).
    METHODS AND RESULTS:
    The structure-inhibitory activity relationships were studied in 30 flavonoids. O-Methylation of a hydroxyl group on an aromatic ring decreased the activity. The prenyl group is important for high inhibitory activity.
    CONCLUSIONS:
    A kinetic study revealed that nor-kurarinone, kurarinol and kurafidin non-competitively inhibit cAMP phosphodiesterase.
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