Kansuinine B
Kansuinine B shows cytotoxic ,and analgesic activities, treatment with kansuinine B and kansuinine A represents a novel method to block the IL-6-induced effects.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Planta Med. 2010 Oct;76(14):1544-9.
Kansuinine A and Kansuinine B from Euphorbia kansui L. inhibit IL-6-induced Stat3 activation.[Pubmed:
20379953]
The current study was performed to examine the mechanisms underlying the potential effects of E. KANSUI on IL-6-induced cellular signaling in human hepatoma cells.
METHODS AND RESULTS:
We found that two diterpenoids, kansuinine A and Kansuinine B, from E. KANSUI have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. Inhibition of MEK significantly blocked the effects of kansuinine A and Kansuinine B on IL-6-induced Stat3 activation and tyrosine phosphorylation. These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and Kansuinine B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression.
CONCLUSIONS:
Treatment with kansuinine A and Kansuinine B represents a novel method to block these IL-6-induced effects.
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