Isolappaol C | CAS:929905-15-7 | Manufacturer ChemFaces

Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cardiovasc Toxicol.2019, 19(4):297-305

Phytochemistry Letters2021, 43:80-87.

Int Immunopharmacol.2019, 71:361-371

Molecules.2023, 28(8):3414.

Food and Bioprocess Technology2017, 10(6):1074-1092

J of the Korean Society of Cosmetics and Cosmetology2018, 399-406

Pharmaceuticals (Basel).2020, 13(10):302.

Cell Physiol Biochem.2019, 52(6):1255-1266

J Agric Food Chem.2017, 65(13):2670-2676

Biosci Biotechnol Biochem.2020, 84(3):621-632

Chemical & Pharmaceutical Bulletin, 2007, 55(1):150-152.

Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production.[Reference: WebLink]

METHODS AND RESULTS:
A new butyrolactone sesquilignan, Isolappaol C (1), together with four known lignans, lappaol C (2), lappaol D (3), lappaol F (4), and diarctigenin (5), were isolated from the methanolic extract of the seeds from the Arctium lappa plant. The structure of Isolappaol C (1) was determined by spectral analysis including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects on the LPS-induced nitric oxide production using murine macrophage RAW264.7 cells.
CONCLUSIONS:
Lappaol F (4) and diarctigenin (5) strongly inhibited NO production in the LPS-stimulated RAW264.7 cells with IC(50) values of 9.5 and 9.6 microM, respectively.

Product Name	Isolappaol C
CAS No.:	929905-15-7
Catalog No.:	CFN95225
Molecular Formula:	C₃₀H₃₄O₁₀
Molecular Weight:	554.6 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The roots of Gymnadenia conopsea
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$333/10mg