Isoneochamaejasmine A
Isoneochamaejasmin A exhibits significantly nematicidal activities against both B. xylophilus and B. mucronatus.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Natural Product Research & Development,2014,26(5):639-44.
Nematicidal Activities of Isoneochamaejasmin A and Neochamaejasmin B from the Roots of Stellera chamaejasme L.against Bursaphelenchus xylophilus and Bursaphelenchus mucronatus[Reference:
WebLink]
METHODS AND RESULTS:
Two biflavonoids were isolated from ethanol extract from the roots of Stellera chamaejasme L.,and their chemical structures were identified as Isoneochamaejasmin A(Isoneochamaejasmine A) and neochamaejasmin B by nuclear magnetic resonance spectral data. The nematicidal activities of the two compounds were tested by bioassay methods with second-stage juveniles(J2s)of Bursaphelenchus xylophilus and Bursaphelenchus mucronatus.
CONCLUSIONS:
The results showed these two biflavonoids exhibited significantly nematicidal activities against both B. xylophilus and B. mucronatus. Neochamaejasmin B displayed better nematicidal activity than isoneochamaejasmin A against two species nematodes under the same conditions.
Drug Metab Dispos. 2014 Apr;42(4):735-43.
Hepatic glucuronidation of isoneochamaejasmin a from the traditional Chinese medicine Stellera chamaejasme L. Root.[Pubmed:
24452863]
Isoneochamaejasmin A (Isoneochamaejasmine A, INCA), a biflavonoid, is one of main active ingredients in the dried root of Stellera chamaejasme L., a widely used traditional Chinese medicine.
METHODS AND RESULTS:
In the present study, we identified the glucuronidation metabolite of Isoneochamaejasmin A and characterized the UDP glucuronosyltransferases (UGTs) responsible for Isoneochamaejasmin A glucuronidation. 7-O-glucuronide (M1) and 4'-O-glucuronide (M2) were identified by incubation of Isoneochamaejasmin A with human liver microsomes (HLMs) in the presence of UDP glucuronic acid, and their structures were confirmed by high-resolution mass spectrometry and nuclear magnetic resonance analyses.
CONCLUSIONS:
Although Isoneochamaejasmin A is a single enantiomer molecule, its M1 metabolite showed two equal-size peaks on a πNAP stationary phase but only one peak on a C(18) stationary phase, indicating that the 7-/7''- and 4'-/4'''-hydroxyl groups of Isoneochamaejasmin A were in different spatial configurations relative to each other.
