Product Name Isochamaejasmine
CAS No.: 93859-63-3
Catalog No.: CFN92150
Molecular Formula: C30H22O10
Molecular Weight: 542.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Targets: NF-kB | PKC | p38MAPK | ERK | Bcl-2/Bax | Caspase | PARP | Antifection
Source: The roots of Stellera chamaejasme Linn.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $418/5mg
Isochamaejasmine has inhibition of NF-kappaB activation, which could reverse the anti-apoptotic effect; it induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins, providing evidence for further studying the underlying anti-cancer mechanism of S. chamaejasme L. Isochamaejasmine shows antiplasmodial activity, with an IC(50) of 7.3+/-3.8 microM, but the selectivity was rather limited.
Inquire / Order:
Technical Inquiries:
Tel: +86-27-84237783
Fax: +86-27-84254680

1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to:

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Exp Parasitol.2018, 194:67-78
  • Front Aging Neurosci.2019, 11:230
  • Am J Chin Med.2015, 30:1-22
  • BMC Complement Altern Med.2017, 17(1):393
  • J Exp Bot.2016, 67(12):3777-88
  • Nutrients.2018, 10(12):E1998
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Exp Neurobiol.2018, 27(3):200-209
  • Pharmacogn Mag.2015, 11:S585-91
  • Food Research International2016, 106-113
  • Chamaejasmenin C

    Catalog No: CFN92061
    CAS No: 89595-70-0
    Price: $498/5mg
    Ruixianglangdusu B

    Catalog No: CFN96558
    CAS No: 447454-49-1
    Price: Inquiry(
    Chamaejasmenin D

    Catalog No: CFN92064
    CAS No: 865852-47-7
    Price: Inquiry(

    Catalog No: CFN92150
    CAS No: 93859-63-3
    Price: $418/5mg
    Isoneochamaejasmine A

    Catalog No: CFN92153
    CAS No: 871319-96-9
    Price: Inquiry(
    Neochamaejasmine B

    Catalog No: CFN92152
    CAS No: 90411-12-4
    Price: $418/5mg
    Neochamaejasmine A

    Catalog No: CFN92151
    CAS No: 90411-13-5
    Price: $418/5mg
    7-Methoxyneochamaejasmine A

    Catalog No: CFN92156
    CAS No: 402828-38-0
    Price: $433/5mg
    Sikokianin A

    Catalog No: CFN92155
    CAS No: 106293-99-6
    Price: $433/5mg
    Sikokianin C

    Catalog No: CFN96514
    CAS No: 159813-69-1
    Price: Inquiry(
    Mol Pharmacol. 2005 Dec;68(6):1534-42.
    Stereospecific induction of nuclear factor-kappaB activation by isochamaejasmin.[Pubmed: 16141313]
    The root of Stellera chamaejasme L. is a traditional Chinese herb termed Rui Xiang Lang Du and has been used to treat solid tumors, tuberculosis and psoriasis. Exactly how S. chamaejasme L. regulates cellular responses remains unclear.
    We examined four biflavonoids isolated from S. chamaejasme L., including isochamaejasmin(Isochamaejasmine), two of its stereo-isomers and a methyl derivative, in functional assays originally designed to screen ligands for the G protein-coupled formyl peptide receptor-like 1 (FPRL1). Isochamaejasmin(Isochamaejasmine) was found to induce the expression of a nuclear factor (NF)-kappaB-directed reporter gene in transfected HeLa cells with an EC50 of 3.23 microM, independently of FPRL1. The isochamaejasmin-stimulated NF-kappaB reporter activity was accompanied by nuclear translocation of NF-kappaB proteins and was blocked by a dominant-negative construct of IkappaBalpha. Isochamaejasmin(Isochamaejasmine) also induced time-dependent phosphorylation of the mitogen-activated protein kinases extracellular signal-regulated kinase 1/2 and p38, and a novel protein kinase C (PKCdelta). Likewise, inhibition of these kinases with the respective pharmacological inhibitors significantly reduced the isochamaejasmin(Isochamaejasmine)-stimulated NF-kappaB activation. It is noteworthy that the two stereoisomers and the methyl derivative did not induce detectable activation of NF-kappaB and were more cytotoxic than isochamaejasmin, which could partially rescue cycloheximide-induced apoptosis. Inhibition of NF-kappaB activation reversed the anti-apoptotic effect of isochamaejasmin(Isochamaejasmine).
    These results provide the first evidence for a potential mechanism of action by S. chamaejasme L., and indicate that structurally similar compounds derived from S. chamaejasme L. may have different pharmacological properties.
    Phytochemistry. 2010 May;71(7):785-91.
    Antiplasmodial activity of (I-3,II-3)-biflavonoids and other constituents from Ormocarpum kirkii.[Pubmed: 20189612 ]
    Preliminary screening of a series of medicinal plants, traditionally used in Tanzania, showed an IC(50) of 15.6-31.2 microg/ml for the crude extract of the root of Ormocarpum kirkii S. Moore (Papilionaceae) against Plasmodium falciparum. A bioguided isolation was performed in order to isolate the active constituents.
    Twelve constituents were obtained and identified using NMR and MS data, and optical rotation measurements. The compounds comprised seven (I-3,II-3)-biflavonoids, three (I-3,II-3)-bi-4-phenyldihydrocoumarins, an isoflavanone and a C-glucosylated flavone. Six compounds, liquiritigeninyl-(I-3,II-3)-naringenin, apigeninyl-(I-3,II-3)-naringenin, 7-O-beta-D-glucopyranosylchamaejasmin, (3R,4S,3''R,4''S)-5,5''-di-O-methyldiphysin, 7-O-beta-D-glucopyranosyldiphysin, and 4''-hydroxydiphysolone, were isolated in addition to six known components. The compounds were evaluated for antimicrobial activity in a broad screening panel, including P. falciparum. Seven of these showed antiplasmodial activity; isochamaejasmin(Isochamaejasmine) being the most active with an IC(50) of 7.3+/-3.8 microM, but the selectivity was rather limited.
    Thus, these constituents may contribute, at least in part, to the antimalarial use of O. kirkii in traditional medicine.
    Chinese Journal of Natural Medicines,2015,13(9):660-6.
    Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins.[Pubmed: 26412425]
    The biflavonoid isochamaejasmin is mainly distributed in the root of Stellera chamaejasme L. (Thymelaeaceae) that is used in traditional Chinese medicine (TCM) to treat tumors, tuberculosis, and psoriasis.
    Herein, isochamaejasmin(Isochamaejasmine) was found to show similar bioactivity against Bcl-2 family proteins to the reference Bcl-2 ligand (-)-gossypol through 3D similarity search. It selectively bound to Bcl-xl and Mcl-1 with Ki values being 1.93 ± 0.13 μmol·L(-1) and 9.98 ± 0.21 μmol·L(-1), respectively. In addition, isochamaejasmin (Isochamaejasmine) showed slight growth inhibitory activity against HL-60 with IC50 value being 50.40 ± 1.21 μmol·L(-1) and moderate growth inhibitory activity against K562 cells with IC50 value being 24.51 ± 1.62 μmol·L(-1). Furthermore, isochamaejasmin(Isochamaejasmine) induced apoptosis of K562 cells by increasing the intracellular expression levels of proteins of the cleavage of caspase-9, caspase-3, and PARP which involved in the Bcl-2-induced apoptosis pathway.
    These results indicated that isochamaejasmin(Isochamaejasmine) induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins, providing evidence for further studying the underlying anti-cancer mechanism of S. chamaejasme L.
    Ginsenoside F1

    Catalog No: CFN99754
    CAS No: 53963-43-2
    Price: $148/20mg
    Chebulinic acid

    Catalog No: CFN92296
    CAS No: 18942-26-2
    Price: $218/10mg

    Catalog No: CFN93199
    CAS No: 94367-42-7
    Price: $188/20mg
    Buddlenoid A

    Catalog No: CFN95025
    CAS No: 142750-32-1
    Price: $368/5mg

    Catalog No: CFN95098
    CAS No: 56994-83-3
    Price: $338/5mg
    Apigenin 7-O-(6''-O-malonylglucoside)

    Catalog No: CFN95163
    CAS No: 86546-87-4
    Price: $318/5mg

    Catalog No: CFN95171
    CAS No: 87095-77-0
    Price: $318/10mg
    Citrusin B

    Catalog No: CFN95178
    CAS No: 105279-10-5
    Price: $388/5mg

    Catalog No: CFN95197
    CAS No: 1809980-25-3
    Price: $318/10mg
    Methylgomisin O

    Catalog No: CFN95236
    CAS No: N/A
    Price: $318/5mg