Gymnestrogenin

Gymnestrogenin
Product Name Gymnestrogenin
CAS No.: 19942-02-0
Catalog No.: CFN90966
Molecular Formula: C30H50O5
Molecular Weight: 490.72 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Targets: Liver X Receptor
Source: The leaves of Gymnema sylvestre.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $268/5mg
Gymnestrogenin has a dual LXRα/β antagonistic profile.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Foods.2022, 11(12):1708.
  • Environ Toxicol.2021, doi: 10.1002
  • Drug Invention Today2019, 12(6):1303-1306
  • Molecules.2019, 24(24):E4536
  • Front Aging Neurosci.2019, 11:230
  • J Sci Food Agric.2017, 97(5):1656-1662
  • Neurochem Res.2021, s11064-021-03449-0
  • J Sep Sci.2018, 41(11):2488-2497
  • Chemistry of Plant Materials.2019, 215-222
  • J Agric Food Chem.2015, 63(44):9869-78
  • Melilotigenin B

    Catalog No: CFN97479
    CAS No: 91269-84-0
    Price: Inquiry(manager@chemfaces.com)
    alpha-Boswellic acid

    Catalog No: CFN98704
    CAS No: 471-66-9
    Price: $238/20mg
    3-O-Acetyl-alpha-boswellic acid

    Catalog No: CFN90529
    CAS No: 89913-60-0
    Price: $338/10mg
    Beta-Peltoboykinolic acid

    Catalog No: CFN96343
    CAS No: 24778-48-1
    Price: Inquiry(manager@chemfaces.com)
    Erythrodiol 3-palmitate

    Catalog No: CFN98004
    CAS No: 19833-13-7
    Price: Inquiry(manager@chemfaces.com)
    23-Hydroxylongispinogenin

    Catalog No: CFN90948
    CAS No: 42483-24-9
    Price: $268/5mg
    Gymnestrogenin

    Catalog No: CFN90966
    CAS No: 19942-02-0
    Price: $268/5mg
    Gymnemagenin

    Catalog No: CFN90961
    CAS No: 22467-07-8
    Price: $268/10mg
    21-O-Tigloylgymnemagenin

    Catalog No: CFN90978
    CAS No: 1581276-63-2
    Price: $268/5mg
    Protoescigenin

    Catalog No: CFN70307
    CAS No: 20853-07-0
    Price: Inquiry(manager@chemfaces.com)
    Steroids. 2015 Apr;96:121-31.
    Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists.[Pubmed: 25668616 ]
    The individual chemical components of commercial extract of Gymnema sylvestre, a medicinal plant used in the traditional systems of the Indian medicine for its antidiabetic and hypolipidemic properties, were isolated and evaluated for their capability to act as modulators of nuclear and membrane receptors involved in glucose and lipid homeostasis.
    METHODS AND RESULTS:
    The study disclosed for the first time that individual gymnemic acids are potent and selective antagonists for the β isoform of LXR. Indeed the above activity was shared by the most abundant aglycone gymnemagenin (10) whereas Gymnestrogenin (11) was endowed with a dual LXRα/β antagonistic profile. Deep pharmacological investigation demonstrated that Gymnestrogenin, reducing the expression of SREBP1c and ABCA1 in vitro, is able to decrease lipid accumulation in HepG2 cells.
    CONCLUSIONS:
    The results of this study substantiate the use of G. sylvestre extract in LXR mediated dislypidemic diseases.
    2-O-cinnamoyl-beta-D-glucose

    Catalog No: CFN95111
    CAS No: N/A
    Price: $318/20mg
    New compound 4

    Catalog No: CFN95185
    CAS No: N/A
    Price: $368/5mg
    Spinacetin

    Catalog No: CFN95194
    CAS No: 3153-83-1
    Price: $318/5mg
    Isolappaol C

    Catalog No: CFN95225
    CAS No: 929905-15-7
    Price: $333/10mg
    (R)-O-isobutyroyllomatin

    Catalog No: CFN95250
    CAS No: 440094-38-2
    Price: $318/5mg
    Physalin X

    Catalog No: CFN95329
    CAS No: 72497-31-5
    Price: $318/5mg
    9,11-Dehydro-beta-boswellic acid

    Catalog No: CFN95335
    CAS No: 471-65-8
    Price: $318/5mg
    New compound 14

    Catalog No: CFN95381
    CAS No: N/A
    Price: $413/5mg
    4'-Hydroxy-5,7,3'-trimethoxyflavone

    Catalog No: CFN95398
    CAS No: 1239-68-5
    Price: $318/5mg
    Neoorthosiphol A

    Catalog No: CFN95447
    CAS No: 243448-72-8
    Price: $318/10mg