Gentisin
Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 uM. Gentisin has mutagenic activity.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
J Plant Biotechnol.2023, 50:070-075.
Cancers (Basel).2023, 15(1):37.
Journal of Apicultural Research2021, 60(1).
Biomed Pharmacother.2022, 145:112410.
Foods.2023, 12(6):1227.
Int J Mol Sci.2023, 25(1):283.
Theoretical and Experimental Plant Physiology 2022, 34,53-62
BMC Plant Biol.2022, 22(1):128.
Biomedicines.2021, 9(8):954.
Fitoterapia.2015, 100:179-86
Related and Featured Products
Euxanthone
Catalog No: CFN98879
CAS No: 529-61-3
Price: Inquiry(manager@chemfaces.com)
Gentisin
Catalog No: CFN89233
CAS No: 437-50-3
Price: Inquiry(manager@chemfaces.com)
Isogentisin
Catalog No: CFN70382
CAS No: 491-64-5
Price: Inquiry(manager@chemfaces.com)
1,7-Dihydroxy-4-methoxyxanthone
Catalog No: CFN89322
CAS No: 87339-76-2
Price: Inquiry(manager@chemfaces.com)
1,3,7-Trihydroxy-2-methoxyxanthone
Catalog No: CFN89266
CAS No: 211948-69-5
Price: Inquiry(manager@chemfaces.com)
1,7-Dihydroxy-2,3-dimethoxyxanthone
Catalog No: CFN89239
CAS No: 78405-33-1
Price: Inquiry(manager@chemfaces.com)
1,7-Dimethoxy-2,3-methylenedioxyxanthone
Catalog No: CFN89256
CAS No: 145523-71-3
Price: Inquiry(manager@chemfaces.com)
1,2,3,7-Tetramethoxyxanthone
Catalog No: CFN89234
CAS No: 22804-52-0
Price: Inquiry(manager@chemfaces.com)
1-Hydroxy-2,3,4,7-tetramethoxyxanthone
Catalog No: CFN96239
CAS No: 14103-09-4
Price: Inquiry(manager@chemfaces.com)
1,2,3,4,7-Pentamethoxy-9H-xanthen-9-one
Catalog No: CFN98534
CAS No: 14254-96-7
Price: Inquiry(manager@chemfaces.com)
Molecules. 2015 Nov 13;20(11):20381-90.
Nonprenylated Xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as Novel Inhibitors of Vascular Smooth Muscle Cell Proliferation.[Pubmed:
26580586 ]
METHODS AND RESULTS:
A natural product screening approach using a resazurin conversion assay enabled the identification of Gentisin (1) from Gentiana lutea as a novel inhibitor of VSMC proliferation with an IC50 value of 7.84 μM. Aiming to identify further anti-proliferative compounds, 13 additional nonprenylated xanthones, isolated from different plant species, were also tested. While some compounds showed no or moderate activity at 30 μM, 1-hydroxy-2,3,4,5-tetramethoxyxanthone (4), swerchirin (6), and methylswertianin (7) showed IC50 values between 10.2 and 12.5 μM. The anti-proliferative effect of 1, 4, 6, and 7 was confirmed by the quantification of DNA synthesis (BrdU incorporation) in VSMC. Cell death quantification (determined by LDH release in the culture medium) revealed that the compounds are not cytotoxic in the investigated concentration range.
CONCLUSIONS:
In conclusion, nonprenylated xanthones are identified as novel, non-toxic VSMC proliferation inhibitors, which might contribute to the development of new therapeutic applications to combat restenosis.
Mutat Res. 1985 Jun-Jul;150(1-2):141-6.
Mutagenicities of xanthone derivatives in Salmonella typhimurium TA100, TA98, TA97, and TA2637.[Pubmed:
3889613]
METHODS AND RESULTS:
The mutagenicities of naturally occurring xanthones were tested in Salmonella typhimurium TA100, TA98, TA97, and TA2637 by the preincubation method. Xanthydrol, gentisein, Gentisin, isoGentisin, 1-hydroxy-3,7-dimethoxyxanthone, 1,3,7-trimethoxyxanthone, desmethylbellidifolin, bellidifolin and dimethylbellidifolin were mutagenic, but unsubstituted xanthone was not mutagenic to TA100, TA98, TA97 and TA2637 with or without a metabolic activation system.
CONCLUSIONS:
The beta-O-glucosides, norswertianolin and swertianolin, were only mutagenic when a metabolic activation system containing beta-glucosidase was used, and the C-glucoside mangiferin was not mutagenic even with this system.