Product Name 1-Isomangostin
CAS No.: 19275-44-6
Catalog No.: CFN95114
Molecular Formula: C24H26O6
Molecular Weight: 410.5 g/mol
Purity: >=98%
Type of Compound: Xanthones
Physical Desc.: Powder
Targets: p65 | NF-kB
Source: The fruits of Garcinia mangostana
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $318/5mg
1-Isomangostin has cytotoxic, and anticomplement activities.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Molecules.2019, 24(6):E1155
  • Int J Mol Sci.2021, 22(8):4211.
  • Nat Prod Sci.2016, 22(2)
  • Journal of Research in Pharmacy.2022, 26(6):p1752-1757.
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Nutrients.2019, 11(6):E1380
  • Molecules.2021, 26(8):2161.
  • Sci Rep.2021, 11(1):21038.
  • Tokyo Pharmaceutical University2020, 500001431953.
  • Oncotarget.2016, 8(51):88386-88400
  • 3-Isomangostin hydrate formate

    Catalog No: CFN97490
    CAS No: 925705-36-8
    Price: Inquiry(manager@chemfaces.com)

    Catalog No: CFN98467
    CAS No: 35349-68-9
    Price: $318/5mg

    Catalog No: CFN99724
    CAS No: 19275-46-8
    Price: $168/10mg
    BR-Xanthone A

    Catalog No: CFN99224
    CAS No: 112649-48-6
    Price: Inquiry(manager@chemfaces.com)

    Catalog No: CFN99856
    CAS No: 184587-72-2
    Price: Inquiry(manager@chemfaces.com)
    Mangostanaxanthone IV

    Catalog No: CFN91525
    CAS No: 2182593-73-1
    Price: Inquiry(manager@chemfaces.com)

    Catalog No: CFN95114
    CAS No: 19275-44-6
    Price: $318/5mg

    Catalog No: CFN91523
    CAS No: 164365-71-3
    Price: Inquiry(manager@chemfaces.com)
    1-Isomangostin hydrate

    Catalog No: CFN98294
    CAS No: 26063-95-6
    Price: Inquiry(manager@chemfaces.com)

    Catalog No: CFN99645
    CAS No: 15404-80-5
    Price: Inquiry(manager@chemfaces.com)
    Nat Prod Commun. 2013 Dec;8(12):1733-4.
    A new xanthone from the pericarp of Garcinia mangostana.[Pubmed: 24555285]

    A new prenylxanthone, garcimangostanol (1), was isolated from the EtOAc-soluble partition of the ethanol extract of the pericarp of Garcinia mangostana L., along with three known compounds, namely 8-deoxygartanin (2), 1-Isomangostin (3), and garcinone C (4). The structure of compound 1 was elucidated on the basis of its 1D, 2D NMR and MS data.
    Compounds 1-4 exhibited either significant o r moderate cytotoxicity against MCF-7, A549, Hep-G2 and CNEhuman cancer cell lines in vitro with IC50 values from 4.0 +/- 0.3 to 23.6+/- 1.5 microM by MTT colorimetric assay.
    J Nat Prod. 2009 Nov;72(11):2028-31
    Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen).[Pubmed: 19839614 ]

    Bioassay-guided fractionation of a chloroform-soluble extract of Garcinia mangostana stem bark, using the HT-29 human colon cancer cell line and an enzyme-based ELISA NF-kappaB assay, led to the isolation of a new xanthone, 11-hydroxy-3-O-methyl-1-Isomangostin (1). The structure of 1 was elucidated by spectroscopic data analysis. In addition, 10 other known compounds, 11-hydroxy-1-Isomangostin (2), 11alpha-mangostanin (3), 3-isomangostin (4), alpha-mangostin (5), beta-mangostin (6), garcinone D (7), 9-hydroxycalabaxanthone (8), 8-deoxygartanin (9), gartanin (10), and cratoxyxanthone (11), were isolated.
    Compounds 4-8 exhibited cytotoxicity against the HT-29 cell line with ED50 values of 4.9, 1.7, 1.7, 2.3, and 9.1 microM, respectively. In an ELISA NF-kappaB assay, compounds 5-7, 9, and 10 inhibited p65 activation with IC50 values of 15.9, 12.1, 3.2, 11.3, and 19.0 microM, respectively, and 6 showed p50 inhibitory activity with an IC50 value of 7.5 microM. Alpha-mangostin (5) was further tested in an in vivo hollow fiber assay, using HT-29, LNCaP, and MCF-7 cells, but it was found to be inactive at the highest dose tested (20 mg/kg).
    Phytother Res. 2010 Oct;24(10):1575-7.
    Xanthone constituents of the fruits of Garcinia mangostana with anticomplement activity.[Pubmed: 20878711]

    Phytochemical investigation of a chloroform-soluble fraction of the freeze-dried fruits of Garcinia mangostana (Clusiaceace) with anticomplement activity in the classical pathway led to the identification of five known xanthones. The structures of these compounds were confirmed by interpretation of NMR and MS spectroscopic data.
    Of the isolates obtained, 1-Isomangostin and garcinone E were found to be active constituents in the anticomplement assay used.
    Polygalasaponin XXXV

    Catalog No: CFN95176
    CAS No: 184479-28-5
    Price: $463/5mg
    9-Octadecenedioic acid

    Catalog No: CFN95301
    CAS No: 4494-16-0
    Price: $218/5mg
    Diosmin Impurity 8

    Catalog No: CFN95309
    CAS No: 28719-21-3
    Price: $318/10mg
    Lathyranoic acid A

    Catalog No: CFN95325
    CAS No: 850560-44-0
    Price: $318/5mg
    New compound 12 (Rhoifolin analog)

    Catalog No: CFN95371
    CAS No: N/A
    Price: $318/5mg

    Catalog No: CFN95387
    CAS No: 56973-42-3
    Price: $318/5mg
    threo-Guaiacylglycerol-beta-coniferyl aldehyde ether

    Catalog No: CFN95417
    CAS No: 650600-33-2
    Price: $318/5mg
    Citrusin C

    Catalog No: CFN95420
    CAS No: 18604-50-7
    Price: $318/10mg
    Quercetin 3,5-O-diglucoside

    Catalog No: CFN95486
    CAS No: 206257-35-4
    Price: $318/5mg
    Ephedrannin D1

    Catalog No: CFN95547
    CAS No: 1592431-55-4
    Price: $318/5mg