7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin
7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells.
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Mol Med Rep.2023 Oct;28(4):193.
Fitoterapia.2022, 105141.
Biorxiv2019, 10.1101
J-STAGE2015, 249-255
Evid Based Complement Alternat Med.2018, 2018:3610494
Kasetsart University2022, ethesis.1144.
Journal of Apicultural Research2021, 60(1)
Int J Mol Sci. 2014, 15(5):8443-57
Sci Rep.2019, 9(1):4342
Molecules.2016, 21(6)
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Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1338-41.
Coumarins from campylotropis hirtella (FRANCH.) SCHINDL. and their inhibitory activity on prostate specific antigen secreted from LNCaP cells.[Pubmed:
18758115]
Campylotropis hirtella (FRANCH.) SCHINDL. was used as a folk medicine for the treatment of benign prostate hyperplasia (BPH) in China.
METHODS AND RESULTS:
In this study, two new coumarins, 7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin (1), 6-[(1S,2S)-2-angeloyloxy-1,3-dihydroxy-3-methylbutyl]-7-methoxycoumarin, named angelol M (2), together with eleven known related compounds (3-13) were isolated from this plant under the bioassay guided fractionation.
CONCLUSIONS:
All the compounds showed activity with different levels in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells, using ELISA method.
