Genistin
Supplementation of Genistin alone or with selenium provides antioxidant defense with high-potential chemopreventive activity against DMBA-induced mammary tumors more than selenium alone.Intravitreal injection of Genistin is safe and effective in reducing traumatic PVR in clinical treatment.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Food Sci Technol. 2014 Oct;51(10):2857-61.
Effect of ultrasound assisted extraction upon the Genistin and Daidzin contents of resultant soymilk.[Pubmed:
25328238]
The purpose of this study was to determine the effect of ultrasound treatment on the contents of daidzin, Genistin, and their respective aglycones, daidzein and genistein, in resultant soymilk.
METHODS AND RESULTS:
Soybean slurry was exposed to ultrasound treatment, filtered, and placed in an ultrasound cleaning bath set with different frequencies (35and 130 KHz), treatment temperatures (20 and 40 °C), and times (20, 40, and 60 min). Concentrations for these isoflavones were determined using reverse-phase high-performance liquid chromatography. Results indicated that both frequencies significantly (p < 0.05) increased isoflavone content (IC), glycosides, and aglycones in extracted soymilk. These results were attributed to induced cavitation, which increases the permeability of plant tissues. However, the frequency of 35 kHz caused a noticeably higher increase in IC than 130 kHz. Results also revealed significant increases in IC with increased sonication time (from 20 to 60 min) and with increased temperature (from 20 to 40 °C).
Toxicol Ind Health. 2012 Sep;28(8):746-57.
Prevention of rat breast cancer by genistin and selenium.[Pubmed:
22089659]
Breast cancer is the second leading cause of cancer death among women and the third most common cancer.
METHODS AND RESULTS:
In this study, we investigated the chemoprevention efficacy of each of soy Genistin, selenium or a combination of them against breast cancer. Seventy-five female rats were divided into five groups : control group (I); 7,12-dimethylbenz(a)anthracene (DMBA) group (II); DMBA treated with Genistin group (III); DMBA treated with selenium group (IV); and DMBA treated with Genistin combined with selenium group (V). The treatments were daily administered for 3 months. There were a significant decrease in body weight and serum total antioxidant, while a significant elevation in serum total sialic acid, carcinoembryonic antigen, prolactin, estradiol, nitric oxide, and malondialdhyde of DMBA injected rats compared with control group. Administration of Genistin and selenium was associated with decreasing levels of tumorigenicity, endocrine derangement, and oxidative stress. Formation of breast carcinoma in DMBA-induced rats and abnormal changes were ameliorated in the rats treated with Genistin/selenium or Genistin alone.
CONCLUSIONS:
Supplementation of Genistin alone or with selenium provided antioxidant defense with high-potential chemopreventive activity against DMBA-induced mammary tumors more than selenium alone.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Jul;35(7):749-53.
Effect of genistin on proliferative vitreoretinopathy.[Pubmed:
20693719]
To examine the effect of Genistin on traumatic proliferative vitreoretinopathy (PVR) in rabbits.
METHODS AND RESULTS:
Traumatic PVR was induced in pigmented rabbits by intravitreal injection of platelet rich plasma. The eyes then received an intravitreal injection of dimethyl sulfoxide (0.1 mL), 2 or 40 μg Genistin (0.1 mL), and 1 mg fluorouracil(0.1 mL), respectively to form 4 groups. The eyes were examined ophthalmoscopically on distinct days after the surgery and the stage of PVR was evaluated. The model eyes and normal eyes in the 40 μg Genistin group carried ERG test on the 28th day. All model eyes in the 4 groups were observed by light microscope on the 28th day. In the control eyes, the retina was detached after 10 d, the PVR had progressed to higher stages with time. In the eyes injected 40 μg Genistin or fluorouracil, the PVR also developed; however, the severity of PVR was lower than that in the control eyes. PVR was significantly inhibited in the 40 μg Genistin group compared with the control eyes after 14 d (P<0.05). Histological examination of the Genistin-treated eyes disclosed no morphological changes, and ERG analysis revealed no significant functional changes.
CONCLUSIONS:
Intravitreal injection of Genistin is safe and effective in reducing traumatic PVR in clinical treatment.
