Genistein 7,4'-di-O-beta-D-glucopyranoside

Genistein 7,4'-di-O-beta-D-glucopyranoside
Product Name Genistein 7,4'-di-O-beta-D-glucopyranoside
CAS No.: 36190-98-4
Catalog No.: CFN90953
Molecular Formula: C27H30O15
Molecular Weight: 594.52 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Targets: Estrogen receptor | Progestogen receptor
Source: The aerial parts of Lupinus hartwegi.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $268/20mg
Genistein 7,4'-di-O-beta-D-glucopyranoside shows significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • BMC Plant Biol.2020, 20(1):214.
  • Pharmacogn Mag.2015, 11:S585-91
  • Phytochemistry.2021, 181:112539.
  • Foods.2024, 13(19):3092.
  • Food Bioscience2024, 57:103518.
  • Bioorg Chem.2024, 145:107184.
  • Appl. Sci.2020, 10(5),1713.
  • Front Microbiol.2022, 12:833233.
  • Front Pharmacol.2022, 13:972825.
  • Appl. Sci.2020, 10(8),2804
  • Delphinidin-3-O-galactoside chloride

    Catalog No: CFN92037
    CAS No: 28500-00-7
    Price: $238/10mg
    Platycoside E

    Catalog No: CFN90786
    CAS No: 237068-41-6
    Price: Inquiry(manager@chemfaces.com)
    Gentisic acid

    Catalog No: CFN92451
    CAS No: 490-79-9
    Price: $40/20mg
    Furanodienone

    Catalog No: CFN92028
    CAS No: 24268-41-5
    Price: $218/20mg
    4-Hydroxybenzaldehyde

    Catalog No: CFN99013
    CAS No: 123-08-0
    Price: $30/20mg
    Plos One, 2014, 9(6):e98559.
    Isolation of Antiosteoporotic Compounds from Seeds of Sophora japonica.[Pubmed: 24892557]
    Chemical investigation of Sophora japonica seeds resulted in the isolation of seven metabolites identified as: genistin (1), sophoricoside (2), sophorabioside (3), sophoraflavonoloside (4), Genistein 7,4'-di-O-beta-D-glucopyranoside (5), kaempferol 3-O-α-L-rhamnopyranosyl(1 → 6)β-D-glucopyranosyl(1 → 2)β-D-glucopyranoside (6) and rutin (7).
    METHODS AND RESULTS:
    Compounds 1, 2 and 5 showed significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range. Compounds 1 and 2 showed minimal cell membrane damaging effect using LDH leakage assay. Accordingly, compound 2 (sophoricoside, (SPH)) was selected for further in-vivo studies as a potential anti-osteoporosis agent. The anti-osteoporotic effect of SPH was assessed in ovarectomized (OVX) rats after oral administration (15 mg/kg and 30 mg/kg) for 45 days compared to estradiol (10 µg/kg) as a positive control. Only in a dose of 30 mg/kg, SPH regained the original mechanical bone hardness compared to normal non-osteoporotic group. However, SPH (15 mg/kg) significantly increased the level of alkaline phosphatase (ALP) to normal level. Treatment with SPH (30 mg/kg) increased the level of ALP to be higher than normal group. SPH (15 mg/kg) did not significantly increase the serum level of osteocalcin (OC) compared to OVX group. On the other hand, treatment with SPH (30 mg/kg) significantly increased the level of OC to 78% higher than normal non-ovarectomized animals group. In addition, SPH (15 mg/kg) decreased the bone resorption marker, acid phosphatase (ACP) to normal level and SPH (30 mg/kg) further diminished the level of serum ACP.
    CONCLUSIONS:
    Histopathologically, sophoricoside ameliorated the ovarectomy induced osteoporosis in a dose dependent manner. The drug showed thicker bony trabeculae, more osteoid, and more osteoblastic rimming compared to OVX group.
    Phytochemistry. 2003 Jun;63(4):449-52.
    Flavone C-glycosides from Lupinus hartwegii.[Pubmed: 12770596]

    METHODS AND RESULTS:
    From the aerial parts of Lupinus hartwegii, two new flavone C-glycosides apigenin-7-O-beta-apiofuranosyl-6, 8-di-C-beta-glucopyranoside (1) and apigenin-7-O-beta-apiofuranosyl-6-C-beta-glucopyranosyl-8-C-(6z.qprime;-O-E-feruloyl)- beta-glucopyranoside (2) have been isolated together with two known isoflavonoid glucosides genistein-7-O-beta-glucopyranoside (3) and Genistein 7,4'-di-O-beta-D-glucopyranoside(4) as well as two known compounds ferulic acid 4-O-beta-glucopyranoside (5) and sparteine (6).
    CONCLUSIONS:
    The structures of the isolated compounds were verified by means of MS and NMR spectral analyses.
    Glucoliquiritin

    Catalog No: CFN95011
    CAS No: 93446-18-5
    Price: $318/10mg
    3''-Galloylquercitrin

    Catalog No: CFN95048
    CAS No: 503446-90-0
    Price: $368/5mg
    5,7,2',4'-Tetrahydroxy-8,3'-di(gamma,gamma-dimethylallyl)-isoflavanone

    Catalog No: CFN95084
    CAS No: 141846-47-1
    Price: $413/5mg
    6''-O-Acetylsaikosaponin D

    Catalog No: CFN95090
    CAS No: 64340-45-0
    Price: $288/5mg
    Cichoriin

    Catalog No: CFN95196
    CAS No: 531-58-8
    Price: $100/20mg
    Biatractylolide

    Catalog No: CFN95205
    CAS No: 182426-37-5
    Price: $268/10mg
    Solafuranone

    Catalog No: CFN95312
    CAS No: 367965-50-2
    Price: $318/5mg
    Lathyranoic acid A

    Catalog No: CFN95325
    CAS No: 850560-44-0
    Price: $318/5mg
    Ganolucidic acid E

    Catalog No: CFN95536
    CAS No: 114567-50-9
    Price: $318/5mg
    1-O-Feruloylglucose

    Catalog No: CFN95596
    CAS No: 64625-37-2
    Price: $413/5mg