Fargesone A
Fargesone A shows inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774.1.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Biosci Biotechnol Biochem. 2008 Oct;72(10):2775-8.
Machilin G and four neolignans from young fruits of Magnolia denudata show various degrees of inhibitory activity on nitric oxide (NO) production.[Pubmed:
18838787]
METHODS AND RESULTS:
Denudatin A and B, denudadione B, Fargesone A and machilin G were isolated from Magnolia denudata. These compounds showed inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774.1.
CONCLUSIONS:
Some but not all of the inhibition of NO production by machilin G, and denudatin A and B was apparently through the decreased expression of the inducible NO synthase (iNOS) gene.
Chem. Pharm. Bull., 1988, 36, 1791-5.
Three new neolignans, fargesones A, B, and C, from the flower buds of Magnolia fargesii[Reference:
WebLink]
Three new neolignans, Fargesone A (I), fargesone B (II) and fargesone C (III), together with two known compounds, denudatin B (IV) and syringin (V), have been isolated from the flower buds of Magnolia fargesii, and their structures determined.
