Fargesone A
Fargesone A shows inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774.1.
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Biosci Biotechnol Biochem. 2008 Oct;72(10):2775-8.
Machilin G and four neolignans from young fruits of Magnolia denudata show various degrees of inhibitory activity on nitric oxide (NO) production.[Pubmed:
18838787]
METHODS AND RESULTS:
Denudatin A and B, denudadione B, Fargesone A and machilin G were isolated from Magnolia denudata. These compounds showed inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774.1.
CONCLUSIONS:
Some but not all of the inhibition of NO production by machilin G, and denudatin A and B was apparently through the decreased expression of the inducible NO synthase (iNOS) gene.
Chem. Pharm. Bull., 1988, 36, 1791-5.
Three new neolignans, fargesones A, B, and C, from the flower buds of Magnolia fargesii[Reference:
WebLink]
Three new neolignans, Fargesone A (I), fargesone B (II) and fargesone C (III), together with two known compounds, denudatin B (IV) and syringin (V), have been isolated from the flower buds of Magnolia fargesii, and their structures determined.
