Fargesone B | CAS:116424-70-5 | Manufacturer ChemFaces

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Vasorelaxation of Rat Aorta by Fargesone B Isolated from the Flower buds of Magnolia Fargesii[Reference: WebLink]

The effect of Fargesone B, isolated from Magnolia fargesii, on the contraction of rat aorta was studied.
METHODS AND RESULTS:
Fargesone B suppressed the contraction of aortic rings caused by cumulative concentrations of calcium (0.03-3 mM) in high potassium (60 mM) medium, with an IC50 of 12 .mu.g ml-1. It also relaxed the norepinephrine (NE, 3 .mu.M)-induced contraction, and its pretreatment inhibited both the phasic and tonic contractions elicited by NE, with an IC50 of about 100 and 30 .mu.g ml-1, respectively. This inhibition was also observed in the absence of calcium in the medium. It did not inhibit caffeine-induced phasic contraction. In quin-2-loaded cultured vascular smooth muscle cells, Fargesone B suppressed the rise of intracellular calcium caused by NE but not that by caffeine. 45Ca++ uptake by NE was also concentration-dependently inhibited by Fargesone B. Fargesone B did not change the levels of PGI2, cGMP or cAMP of rat aorta.
CONCLUSIONS:
It is concluded that Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium influxes in a nonselective

Product Name	Fargesone B
CAS No.:	116424-70-5
Catalog No.:	CFN96260
Molecular Formula:	C₂₁H₂₄O₆
Molecular Weight:	372.4 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Oil
Targets:	Calcium Channel \| cAMP
Source:	The flowers of Magnolia fargesii
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: