Product Name Isonardosinone
CAS No.: 27062-01-7
Catalog No.: CFN95180
Molecular Formula: C15H20O4
Molecular Weight: 264.3 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Oil
Targets: NF-κB | MAPK
Source: The rhizomes and roots of Nardostachys chinensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $318/10mg
Isonardosinone shows potential role in the treatment of neuroinflammation conditions, it inhibits NF-κB- and MAPK-mediated inflammatory pathways.
Inquire / Order:
Technical Inquiries:
Tel: +86-27-84237783
Fax: +86-27-84254680

1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to:

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Molecules.2019, 24(19):E3417
  • Academic J of Second Military Medical University2019, 40(1)
  • Molecules.2019, 24(6):E1155
  • BMC Complement Altern Med.2019, 19(1):339
  • Molecules.2016, 21(6)
  • PLoS One.2015, 10(5):e0127060
  • Pharmacol Rep.2017, 69(6):1224-1231
  • Neuropharmacology2019, 151437
  • ACS Chem Biol.2019, 14(5):873-881
  • Sci Rep.2017, 7:467-479
  • Kanshone A

    Catalog No: CFN96977
    CAS No: 115356-18-8
    Price: $318/5mg

    Catalog No: CFN89546
    CAS No: 20489-11-6
    Price: Inquiry(

    Catalog No: CFN95180
    CAS No: 27062-01-7
    Price: $318/10mg
    Narchinol B

    Catalog No: CFN89522
    CAS No: 1356822-09-7
    Price: Inquiry(
    Desoxo-narchinol A

    Catalog No: CFN89358
    CAS No: 53859-06-6
    Price: Inquiry(

    Catalog No: CFN98699
    CAS No: 4674-50-4
    Price: $40/20mg
    Tessaric acid

    Catalog No: CFN95182
    CAS No: 58142-10-2
    Price: $318/5mg

    Catalog No: CFN90178
    CAS No: 23720-80-1
    Price: $128/20mg
    Kanshone B

    Catalog No: CFN89423
    CAS No: 115370-61-1
    Price: Inquiry(

    Catalog No: CFN96139
    CAS No: 6831-17-0
    Price: $298/20mg
    Inflammation. 2018 Aug;41(4):1215-1228.
    Nardosinone-Type Sesquiterpenes from the Hexane Fraction of Nardostachys jatamansi Attenuate NF-κB and MAPK Signaling Pathways in Lipopolysaccharide-Stimulated BV2 Microglial Cells.[Pubmed: 29616391 ]

    Four nardosinone-type sesquiterpenes, nardosinone, Isonardosinone, kanshone E, and kanshone B, were isolated from the hexane fraction of Nardostachys jatamansi (Valerianaceae) methanol extract. The structures of these compounds were mainly established by analyzing the data obtained from nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). In this study, we investigated their anti-neuroinflammatory effects in lipopolysaccharide (LPS)-induced BV2 microglial cells. The results showed that nardosinone-type sesquiterpenes inhibited the production of pro-inflammatory mediators, such as nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-induced BV2 microglial cells. These inhibitory effects were correlated with the downregulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, these sesquiterpenes also attenuated the mRNA expression of pro-inflammatory cytokines including interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) in LPS-induced BV2 microglial cells. During the evaluation of the signaling pathways involved in these anti-neuroinflammatory effects, western blot analysis and DNA-binding activity assay revealed that the suppression of inflammatory reaction by these sesquiterpenes was mediated by the inactivation of nuclear factor-kappa B (NF-κB) pathway. These sesquiterpenes also suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) signaling pathways in LPS-stimulated BV2 microglial cells.
    Taken together, these four nardosinone-type sesquiterpenes inhibited NF-κB- and MAPK-mediated inflammatory pathways, demonstrating their potential role in the treatment of neuroinflammation conditions.
    Ganoderic acid H

    Catalog No: CFN92056
    CAS No: 98665-19-1
    Price: $399/5mg
    3-O-Feruloylquinic acid

    Catalog No: CFN92393
    CAS No: 1899-29-2
    Price: $488/5mg

    Catalog No: CFN96001
    CAS No: 1092952-62-9
    Price: $413/5mg
    Forsythoside E

    Catalog No: CFN90642
    CAS No: 93675-88-8
    Price: $188/10mg
    Tubuloside A

    Catalog No: CFN90669
    CAS No: 112516-05-9
    Price: $218/20mg
    Caohuoside E

    Catalog No: CFN95016
    CAS No: 174286-23-8
    Price: $388/5mg

    Catalog No: CFN95021
    CAS No: 1178-24-1
    Price: $268/10mg
    Torosachrysone 8-O-beta-gentiobioside

    Catalog No: CFN95131
    CAS No: 94356-13-5
    Price: $318/5mg

    Catalog No: CFN95196
    CAS No: 531-58-8
    Price: $100/20mg
    Bruceantinol B

    Catalog No: CFN95216
    CAS No: 1822332-33-1
    Price: $318/5mg