Docosyl caffeate
Docosyl caffeate shows moderate antioxidant activity in DPPH and ABTS scavenging assays, it also has significant anti-inflammation activity. Docosyl caffeate exhibits potent elastase inhibitory activity, with the IC50 value of 1.4 microg/mL.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Nat Prod Res. 2009;23(18):1657-63.
Bioactive caffeic acid esters from Glycyrrhiza glabra.[Pubmed:
19921583]
METHODS AND RESULTS:
Thin layer chromatography bioautography (using DPPH spray reagent) guided fractionation of Glycyrrhiza glabra led to the isolation of two caffeic acid derivative esters, viz. eicosanyl caffeate (1) and Docosyl caffeate (2). The two compounds exhibited potent elastase inhibitory activity, with IC(50) values of 0.99 microg mL(-1) and 1.4 microg mL(-1) for 1 and 2, respectively. The compounds also showed moderate antioxidant activity in DPPH and ABTS scavenging assays.
CONCLUSIONS:
The results indicate a possible role of caffeic acid derivatives, in addition to flavonoids in the anti-ulcer properties of G. glabra.
Academic Journal of Second Military Medical University, 2008,28(10):1221-6.
Anti-inflammatory constituents from the stems of Daphne genkwa.[Reference:
WebLink]
To study the anti-inflammation contents in the stems of Daphne genkwa.
METHODS AND RESULTS:
The anti-inflammation contents were obtained from Daphne genkwa by bio-assay guide isolating method. The pharmacological model of dimethylbenzene-induced ear swelling was used for pharmacological study. The fractions of Ligroine and chloroform part of the the EtOH extraction were isolated and purified by column chromatography on silica gel and Sephadex LH-20 and recrystallization. Their structures were studied by using UV, IR,1 H-NMR,13 C-NMR, and MS, techniques. Nineteen compounds were isolated from the stems of Daphne genkwa and were identified as 2, 3-dihydroxypropyl hexadecoate(1), β-sitosterol(2), dueicosanyl caffeate(3), Docosyl caffeate(4), octadecyl caffeate(5), daucosterol(6), genkwanin(7), luteolin(8), (+) lariciresinol (9), apigenin (10), kaempferol (11), daphnodorin B (12), genistein (13), dihydrokaempferol (14), p-hydroxybenzonic acid (15), quercetin (16), syringin (17), syringaldehyde (18), ethyl 4-hydroxybenzoate (19).
CONCLUSIONS:
Compounds 1, 3-5, 7, 15, 17-19 have been isolated from the stems of Daphne genkwa for the first time. The high dosage of petroleum ether extract, chloroform extract and compound 4 have significant anti-inflammation activity in mice with ear swelling.
