7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of Alzheimer's disease (AD).
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Phytother Res.2022, 35844057.
Plant Cell Tiss Org2017, 479-486
J Ethnopharmacol.2022, 289:115018.
J Sep Sci.2020, 43(22):4148-4161.
Agronomy 2021, 11(3),502.
Plos One.2020, 10.1371
Sci Rep.2019, 9(1):6429
Plants (Basel).2021, 10(4):702.
Food Res Int.2019, 123:125-134
J Agric Food Chem.2020, 68(43):12164-12172.
5-Hydroxy-1-(4-hydroxyphenyl)-7-phenyl-3-heptanone (AO 2210)
Catalog No: CFN95137
CAS No: 105955-04-2
Catalog No: CFN95195
CAS No: 87095-75-8
Catalog No: CFN95227
CAS No: 232261-31-3
Catalog No: CFN97433
CAS No: 87095-74-7
Catalog No: CFN95135
CAS No: 79559-61-8
Catalog No: CFN92686
CAS No: 1041740-13-9
Catalog No: CFN92257
CAS No: 936006-13-2
Catalog No: CFN92628
CAS No: 60669-64-9
Catalog No: CFN92258
CAS No: 54835-64-2
Catalog No: CFN92685
CAS No: 79559-59-4
Biol Pharm Bull. 2016 Dec 1;39(12):1961-1967.
7-(4-Hydroxyphenyl)-1-phenyl-4E-hepten-3-one, a Diarylheptanoid from Alpinia officinarum, Protects Neurons against Amyloid-β Induced Toxicity.[Pubmed: 27615431
Amyloid-β (Aβ) is one of the major causative agents of Alzheimer's disease (AD), the most common neurodegenerative disorder characterized by progressive cognitive impairment. While effective drugs for AD are currently limited, identifying anti-Aβ compounds from natural products has been shown as a promising strategy which may lead to breakthroughs for new drug candidate discovery. We have previously reported that 7-(4-hydroxyphenyl)-1-phenyl-4E-hepten-3-one (7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
,AO-1), a diarylheptanoid extracted from the plant Alpinia officinarum, has strong effects on neuronal differentiation and neurite outgrowth in vitro and in vivo.
METHODS AND RESULTS:
The present study further uncovers that AO-1 exerts neuroprotective effects against the neurotoxicity caused by Aβ. Under the damage of Aβ oligomers, the major pathological forms of Aβ, dendrites of neurons become atrophic and simplified, but such impairments were substantially alleviated by AO-1 treatment. Moreover, AO-1 reduced apoptotic levels and oxidative stress triggered by Aβ. Further analysis showed that the anti-caspase and dendrite protective effects of AO-1 were dependent on activation of phosphatidylinositol 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) pathways.
These findings collectively identify AO-1 as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of AD.