Cyclo(Ile-Leu)
Cyclo(Ile-Leu) shows cytotoxic activity in vitro.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Pest Manag Sci.2019, 75(9):2530-2541
J Ginseng Res.2020, 44(4):611-618.
Evid Based Complement Alternat Med.2016, 2016:1739760
Evid-Based Compl Alt2020, 7202519:13
Chin J Pharm Anal.2019, 39(7):1217-1228
Biofactors.2018, 44(2):168-179
Mol Biol Rep.2024, 51(1):117.
Biomol Ther (Seoul).2024, 32(2):214-223.
TCI CO.2019, US20190151281A1
Front Mol Neurosci.2023, 15:1083189.
Related and Featured Products
《Journal of Shenyang Pharmaceutical University》 2007-08
Cyclic dipeptide constituents from the mangrove fungus Penicillium oxalicum(No.092007)[Reference:
WebLink]
To study the metabolites of mangrove fungus Penicillium oxalicum from the south China sea and search for new anti-tumor compounds.
METHODS AND RESULTS:
Compounds were isolated by silica gel,ODS column chromatography,Sephadex LH-20 column chromatography and reversed-phase HPLC purification.Structural elucidation was achieved by physico-chemical constants and spectroscopic analysis
MTT assay was used to evaluate the bioactivities in vitro.Six cyclic dipeptides were isolated from the acetone extracts of mycelium of fungus and elucidated as cyclo-(Phe-Ile)(1),cyclo-(Phe-Val)(2),Cyclo(Ile-Leu)(3),cyclo-(Val-Val)(4),cyclo-(Pro-Val)(5),cyclo-(Pro-Gly)(6).Coumpouds 2,3 and 5 could evidently inhibit the growth of cancer cell lines HepG Ⅱ and LNCaP at the concentration of 50 μg·mL-1.
CONCLUSIONS:
All of Compounds are obtained from the marine fungus for the fist time.Compounds 2,Cyclo(Ile-Leu) and 5 show cytotoxic activity in vitro.
