Cyclo(Leu-Leu)
Cyclo(Leu-Leu) is an efficient supramolecular catalyst.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Biomed Pharmacother.2020, 131:110673.
Korean Herb. Med. Inf. 2016, 4(1):35-42
Nutrients.2023, 15(24):5020.
The Korea Journal of Herbology2020, 35(3):33-45.
Food Sci Nutr.2019, 8(1):246-256
J AOAC Int.2021, 104(6):1634-1651.
Evid Based Complement Alternat Med.2021, 2021:8847358.
Journal of Research in Pharmacy.2022, 26(6):p1752-1757.
Cells.2022, 11(6):931.
Life Sci.2022, 311(Pt A):121157.
Related and Featured Products
Supramolecular Chemistry, 2017,29(5):330- 49.
Interfacial supramolecular biomimetic epoxidation catalysed by cyclic dipeptides[Reference:
WebLink]
METHODS AND RESULTS:
We synthesised a library of cis- and trans-cyclic dipeptides and evaluated their efficacy as catalysts in the asymmetric Weitz-Scheffer epoxidation of trans-chalcone. A thorough investigation relying on structure-activity studies and computational studies provided insights into the mechanism of the process. Our results revealed some structural features required for efficient conversion and for introduction of chirality into the product. The cyclic dipeptide acts as a catalyst by templating a supramolecular arrangement at the aqueous-organic interface required for efficient transformations to occur.
CONCLUSIONS:
Among all cyclic dipeptides investigated, Cyclo(Leu-Leu) was the most efficient supramolecular catalyst.
