Cyclo(Ile-Ala)
Cyclo(Ile-Ala) is a new cell cycle inhibitor.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Journal of Shenyang Pharmaceutical University, 2015 (2) :107 -10.
Cyclic dipeptides as new cell cycle inhibitors produced by Streptomyces flavoretus 18522[Reference:
WebLink]
To find the cell cycle inhibitors from the metabolites of Streptomyces flavoretus 18522.
METHODS AND RESULTS:
Activity-guided isolation was performed on the chloroform extract of the fermentation broth and mycelia of Streptomyces flavoretus 18522 by using ts FT210 cells.Compounds were isolated through various chromatoghraphic methods and elucidated by spectroscopic means.The flow cytometry was used to evaluate the cell cycle inhibiting activity of the fractions and compounds. Six cyclic dipeptides were obtained and identified as cyclo(Ala-Leu)(1),Cyclo(Ile-Ala) (2),cyclo(Ala-Val)(3),cyclo(Phe-Leu)(4),cyclo(Ala-Pro)(5) and cyclo(Phe-Val)(6).
CONCLUSIONS:
Compounds 1-6 are reported as new cell cycle inhibitors for the first time.
《Chinese Journal of Natural Medicines》 2007-01
Chemical Constituents of the Seeds of Euryale ferox[Reference:
WebLink]
To investigate the chemical constituents in the seeds of Euryale ferox Salisb for obtaining a more comprehensive understanding on its effective components.
METHODS AND RESULTS:
Compounds were separated by column chromatography with silica gel, Pharmadex LH-20 and reversed-phase silica gel. Their structures were elucidated by spectral analysis and chemical evidence. Seven compounds and a mixture of two compounds were obtained. Their structures were identified as: Cyclo(Pro-Ser) (1), Cyclo(Ile-Ala) (2), Cyclo(Leu-Ala) (3), 5,7,4′-trihydroxy-flavanone (4), 5,7,3′,4′,5′-pentahydroxy-flavanone (5), isolariciresinol-9-O-β-D-glucopyranoside (6), α-tocopherol (7), β-tocopherol (8), δ-tocopherol (9).
CONCLUSIONS:
Compound 1 was firstly isolated from natural sources; compounds 2-6 have been isolated from this plant for the first time.
