Cyclo(Ile-Val)
Cyclo(Ile-Val) shows moderate antifungal and weak antitumor activities in vitro.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Tetrahedron Lett.,2002,33(51):6545-8.
Antifungal cyclopeptides from Halobacillus litoralis YS3106 of marine origin[Reference:
WebLink]
METHODS AND RESULTS:
Three new cyclopeptides, including halolitoralin A (a cyclic hexapeptide), halolitoralin B and C (two cyclic tetrapeptides), together with three known cyclic dipeptides, cyclo(Pro-Val), cyclo(Pro-Leu) and Cyclo(Ile-Val) were isolated from the ferment broth of a marine sediment-derived Halobacillus litoralis YS3106.
CONCLUSIONS:
The cyclopeptides show surprisingly simple architectures with highly repeated residue units, which showed moderate antifungal and weak antitumor activities in vitro.
《Chinese Journal of Marine Drugs》 2014-03
Research on cyclo-dipeptides from the Coral-derived bacteria Brevibacterium sp.of South China Sea(Ⅱ)[Reference:
WebLink]
To study cyclo-dipeptides from the Coral-derived bacteria Brevibacterium sp.of South China Sea.
METHODS AND RESULTS:
Compounds were isolated by all kinds of column chromatography,such as silica gel,Sephadex LH-20,ODS,and purified by HPLC.Their structures were identified by spectroscopic analysis(NMR,MS,GC-MS,and so on),chemicophysical methods,and compared with references. Twelve compounds were isolated from the fermentation broth of Coral-derived bacteria L-4of South China Sea,and their structures were determined as cyclo-(Trp-Thr)(1),cyclo-(4-OH-ProTyr)(2),cyclo-(Leu-Tyr)(3),cyclo-(Phe-Ala)(4),cyclo-(Ile-Gly)(5),cyclo-(Leu-Gly)(6),cyclo-(Leu-Pro)(7),cyclo-(Leu-Ala)(8),cyclo-(Ile-Ala)(9),cyclo-(Leu-Thr)(10),Cyclo(Ile-Val)(11),cyclo-(Ile-Ile)(12).
CONCLUSIONS:
All compounds were cyclo-dipeptides and first obtained from the marine Coral-derived bacteriumBrevibacteriumsp.
