Curcumadione
Curcumadione shows certain acetylcholinesterase inhibitory activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Wageningen University & Research2018, January 2018
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iScience.2020, 23(2):100849.
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Sci Rep.2023, 13(1):13610.
Int J Mol Sci.2022, 23(11):6172.
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Food Chemistry: X.2022, 2022.100270
Plants (Basel).2021, 10(11):2525.
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Journal of Shandong University, 2013,48(7):20-3.
Chemical constituents of Curcuma xanthorrhiza Roxb. and their acetylcholinesterase inhibitory activity[Reference:
WebLink]
METHODS AND RESULTS:
Chemical constituents from Curcuma xanthorrhiza Roxb. (Zingiberaceae) rhizome were isolated and purified by column chromatography (silica gel, RP silica gel MPLC, HPLC) and their structures were elucidated on the basis of spectral analyses. Six compounds were identified by MS and NMR spectroscopy as zederone(I), beta-sitosterol(II), Guai-1(10),3,5,7(11),8-pentaen-2-on-11,8-olide(III), Curcumadione(IV), Curcumenone (V), Cuparenol (VI). Compound III and VI were isolated for the first time from the plants of Zingiberaceae, and compound IV and V were isolated from Curcuma xanthorrhiza Roxb. for the first time. Meanwhile, the acetylcholinesterase inhibitory activity of the isolated compounds was evaluated.
CONCLUSIONS:
Compounds IV and VI showed certain inhibitory activity, the minimum inhibitory quantity of IV on TLC bioautography test was 95ug.
J Nat Med. 2009 Jan;63(1):102-4.
Sesquiterpenes from Curcuma comosa.[Pubmed:
18663560]
METHODS AND RESULTS:
From the dried rhizomes of Curcuma comosa cultivating in Thailand, 26 known sesquiterpenes were isolated: zederone, zederone epoxide, furanodienone, isofuranodienone, 1(10)Z,4Z-furanodiene-6-one, glechomanolide, dehydrocurdione, neocurdione, curdione, 7 alpha-hydroxyneocurdione, 7 beta-hydroxycurdione, germacrone-1(10),4-diepoxide, germacrone, 13-hydroxygermacrone, curzerenone, curcolonol, alismol, alismoxide, zedoarondiol, isozedoarondiol, procurcumenol, isoprocurcumenol, aerugidiol, zedoalactone B, curcumenone, and Curcumadione. Their structures were elucidated on the basis of physicochemical evidence.
CONCLUSIONS:
Among them, glechomanolide, curzerenone, curcolonol, alismol, alismoxide, and zedoarondiol showed no significant optical activities, so they may be artifact products during the isolation or drying process.
Zhongguo Zhong Yao Za Zhi. 2008 Apr;33(7):785-8.
Sesquiterpenes from stems and leaves of Curcuma wenyujin.[Pubmed:
18589781]
To study the chemical constituents of the stem and leaves from Curcuma wenyujin.
METHODS AND RESULTS:
The compounds were isolated by silica gel column chromatography in associating with Sephadex LH -20 chromatography. While their structures were identified on the basis of spectroscopic date.
Nine sesquiterpenes were isolated and identified. Their structures were identified as curdione (1), neocurdione (2), trans, trans-germacrone (3), cis, trans-germacrone (4), curcumenone (5), Curcumadione (6), isoprocurcumenol (7), glechomanolide (8) and (1R, 10R)-( -)-1, 10-dihydrocurdione (9).
CONCLUSIONS:
All of these compounds were isolated from the stems and leaves of this plant for the first time.
