Curcumadione

Journal of Shandong University, 2013,48(7):20-3.

Chemical constituents of Curcuma xanthorrhiza Roxb. and their acetylcholinesterase inhibitory activity[Reference: WebLink]

METHODS AND RESULTS:
Chemical constituents from Curcuma xanthorrhiza Roxb. (Zingiberaceae) rhizome were isolated and purified by column chromatography (silica gel, RP silica gel MPLC, HPLC) and their structures were elucidated on the basis of spectral analyses. Six compounds were identified by MS and NMR spectroscopy as zederone(I), beta-sitosterol(II), Guai-1(10),3,5,7(11),8-pentaen-2-on-11,8-olide(III), Curcumadione(IV), Curcumenone (V), Cuparenol (VI). Compound III and VI were isolated for the first time from the plants of Zingiberaceae, and compound IV and V were isolated from Curcuma xanthorrhiza Roxb. for the first time. Meanwhile, the acetylcholinesterase inhibitory activity of the isolated compounds was evaluated.
CONCLUSIONS:
Compounds IV and VI showed certain inhibitory activity, the minimum inhibitory quantity of IV on TLC bioautography test was 95ug.

J Nat Med. 2009 Jan;63(1):102-4.

Sesquiterpenes from Curcuma comosa.[Pubmed: 18663560]

METHODS AND RESULTS:
From the dried rhizomes of Curcuma comosa cultivating in Thailand, 26 known sesquiterpenes were isolated: zederone, zederone epoxide, furanodienone, isofuranodienone, 1(10)Z,4Z-furanodiene-6-one, glechomanolide, dehydrocurdione, neocurdione, curdione, 7 alpha-hydroxyneocurdione, 7 beta-hydroxycurdione, germacrone-1(10),4-diepoxide, germacrone, 13-hydroxygermacrone, curzerenone, curcolonol, alismol, alismoxide, zedoarondiol, isozedoarondiol, procurcumenol, isoprocurcumenol, aerugidiol, zedoalactone B, curcumenone, and Curcumadione. Their structures were elucidated on the basis of physicochemical evidence.
CONCLUSIONS:
Among them, glechomanolide, curzerenone, curcolonol, alismol, alismoxide, and zedoarondiol showed no significant optical activities, so they may be artifact products during the isolation or drying process.

Zhongguo Zhong Yao Za Zhi. 2008 Apr;33(7):785-8.

Sesquiterpenes from stems and leaves of Curcuma wenyujin.[Pubmed: 18589781]

To study the chemical constituents of the stem and leaves from Curcuma wenyujin.
METHODS AND RESULTS:
The compounds were isolated by silica gel column chromatography in associating with Sephadex LH -20 chromatography. While their structures were identified on the basis of spectroscopic date. Nine sesquiterpenes were isolated and identified. Their structures were identified as curdione (1), neocurdione (2), trans, trans-germacrone (3), cis, trans-germacrone (4), curcumenone (5), Curcumadione (6), isoprocurcumenol (7), glechomanolide (8) and (1R, 10R)-( -)-1, 10-dihydrocurdione (9).
CONCLUSIONS:
All of these compounds were isolated from the stems and leaves of this plant for the first time.