Chlorahololide C

Chlorahololide C
Product Name Chlorahololide C
CAS No.: 1007859-25-7
Catalog No.: CFN96953
Molecular Formula: C33H36O9
Molecular Weight: 576.64 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Targets: Potassium Channel
Source: The whole plants of Chloranthus holostegius.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Chlorahololide C is a potent and selective potassium channel blocker, it exerts potent and selective inhibition on the delayed rectifier (I(K)) K(+) current with the IC(50) value of 3.6 +/- 10.1 mu M.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Tetrahedron, 2008, 64(9):2027-2034.
    Chlorahololides C–F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius[Reference: WebLink]

    METHODS AND RESULTS:
    Four unusually fused polycyclic sesquiterpenoid dimers, Chlorahololide C,chlorahololide D, chlorahololide E, chlorahololide F (1 - 4), were isolated from the whole plant of Chloranthus holostegius. Their structures and absolute configurations were established by spectroscopic methods, including 2D NMR and CD spectra.
    CONCLUSIONS:
    Chlorahololides C - F (1 - 4) exerted potent and selective inhibition on the delayed rectifier (I(K)) K(+) current with the IC(50) values of 3.6 +/- 10.1, 2.7 +/- 0.3, 27.5 +/- 5.1. and 57.5 +/- 6.1 mu M, respectively.
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