Chloranthalactone E

Phytomedicine. 2018 Oct 1;49:23-31

In vitro inhibitory properties of sesquiterpenes from Chloranthus serratus on cell motility via down-regulation of LIMK1 activation in human breast cancer[Pubmed: 30217259]

Three sesquiterpenes, Chloranthalactone E (compound 1), serralactone A (compound 2, SERA is used in the further testing), and 8β, 9α-dihydroxylindan-4(5), 7(11)-dien-8α, 12-olide (compound 3) were isolated from Chloranthus serratus, and the anti-LIMK1 activities of these compounds were investigated by kinase-Glo® luminescent kinase assay.

Zhong Yao Cai. 2015 Oct;38(10):2087-90.

Sesquiterpenes of Chloranthus serratus Root.[Pubmed: 27254920]

To study sesquiterpenes from the root of Chloranthus serratus.
METHODS AND RESULTS:
The sesquiterpenes of Chloranthus serratus were isolated and purified by various chromatographic techniques, such as silica gel, Sephadex LH-20 and preparative HPLC. The structures of these isolated compounds were identified by spectroscopic analysis. Ten sesquiterpenes were isolated and identified as follows: 1β, 8β-dihydroxy-eudesman-4 (15), 7 (11) -dien-8α, 12-olide (I), curcolonol (II), 4β, 8β-dihydroxy-5α (H) -eudesm-7 (11) -en-8, 12-olide (III), 1β, 8,β-dihydroxy-eudesman-3, 7 (11) -dien-8α, 12-olide (IV), multistalactone E (V), zedoarofuran (VI), 8β,9α-dihydroxylindan-4(5), 7(11) -dien-8α,12-olide(VII), serralactone A (VIII), 8-epi-ivangustin (IX), and Chloranthalactone E (X ).
CONCLUSIONS:
Compounds I, II, IV - VII, IX and X are isolated from Chloranthus serratus for the first time.