Chicanine

Chicanine
Product Name Chicanine
CAS No.: 78919-28-5
Catalog No.: CFN90914
Molecular Formula: C20H22O5
Molecular Weight: 342.39 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Targets: NO | PGE | NF-kB | COX | TNF-α | NOS | ERK | p38MAPK | TLR | IkB | IKK
Source: The fruits of Osmanthus fragrans.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $313/5mg
Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα/MAPK/ERK signaling pathways. Chicanine also has good anti-proliferation (IC₅₀=44.2uM) on prostate cells and antioxidant activities (IC₅₀=26.0 uM,) with no significant toxic effects on normal cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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  • Trop J Nat Prod Res.2019, 3(1):6-9
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  • Food Chem.2021, 360:130063.
  • J Mater Chem B.2019, 7(39):5896-5919
  • Front Plant Sci.2018, 9:1424
  • Mol Cells.2015, 38(9):765-72
  • Korean Herb. Med. Inf.2020, 8(2):233-242.
  • Int J Mol Sci.2021, 22(14):7324.
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    Anti-inflammatory effects of chicanine on murine macrophage by down-regulating LPS-induced inflammatory cytokines in IκBα/MAPK/ERK signaling pathways[Pubmed: 24361309 ]
    Schisandra chinensis Baill is a Chinese traditional medicine with multiple pharmacological activities.
    METHODS AND RESULTS:
    In this study, Chicanine, one of the major lignan compounds of S. chinesis, was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages (RAW 264.7 cells). Chicanine was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO) and Prostaglandin E (2) (PGE2) production and nuclear factor-κB (NF-κB) signaling in LPS-stimulated RAW 264.7 cells with no cytotoxic effects. Treatment of RAW 264.7 cells with Chicanine down-regulated LPS-induced expression of pro-inflammatory cytokines including TNFα, IL-1β, MCP-1, G-CSF, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinases 1 and 2 (ERK 1/2), and also IκB-α phosphorylation.
    CONCLUSIONS:
    These results indicated that anti-inflammatory actions of Chicanine in macrophages involved inhibition of LPS-induced TLR4-IκBα/MAPK/ERK signaling pathways.
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    Schisandra chinensis fruit has been used as functional foods and traditional Chinese medicine for thousands years. In order to illustrate the main active components, one triterpenoid and four lignan compounds were isolated from Schisandra chinensis.
    METHODS AND RESULTS:
    The antioxidant and anti-proliferative activities of the five compounds and extract were evaluated by DPPH radical-scavenging assay and MTT assay on prostate cancer cells PC3. The structures of the compounds were fully characterized, which were d-epigalbacin, machilin G, Chicanine, anwulignan, and epi-anwuweizic acid, respectively. Activity results showed that epi-anwuweizic acid had the highest cytotoxic activity on prostate cells (IC₅₀=36.5μM) but lower antioxidant activities. Chicanine had good anti-proliferation (IC₅₀=44.2μM) and antioxidant activities (IC₅₀=26.0μM,) with no significant toxic effects on normal cells.
    CONCLUSIONS:
    The results suggested that there were lignan and triterpenoid compounds in Schisandra chinensis to have biological activities on diseases associated with aging and cancer.
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    All compounds were isolated from the osmanthus fruit for the first time. Except for compounds 4, 7, 15, 19, 23, the rest ones were isolated from the this plant for the first time.
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