Futokadsurin C
Futokadsurin C can inhibit nitric oxide production by a murine macrophage-like cell line (RAW 264.7), which is activated by lipopolysaccharide and interferon-gamma.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Current Enzyme Inhibition2023, 19(1):55-64(10)
J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
J Ethnopharmacol.2017, 197:157-164
Biomed Chromatogr.2022, 36(11):e5462.
J Mol Med (Berl).2018, 96(7):661-672
Comput Biol Chem.2019, 83:107096
World J Mens Health.2019, 10.5534
Separations2023, 10(4), 231.
Food Control2022, 132:108434.
Phytother Res.2015, 29(7):1088-96
Related and Featured Products
Chem Pharm Bull (Tokyo). 2005 Jan;53(1):121-4.
Neolignans from Piper futokadsura and their inhibition of nitric oxide production.[Pubmed:
15635246]
METHODS AND RESULTS:
From a MeOH extract of the aerial part of Piper futokadsura, the tetrahydrofuran lignans, futokadsurin A [(7S,8S,7'S,8'R)-3,4,3'-trimethoxy-4'-hydroxy-7,7'-epoxylignan], futokadsurin B [(7R,8R,7'R,8'S)-3,4-dimethoxy-3',4'-methylenedioxy-7,7'-epoxylignan], and Futokadsurin C [(7R,8R,7'S,8'S)-3,4-methylenedioxy-3',4'-dimethoxy-7,7'-epoxylignan] were isolated, together with nine known neolignans. In addition, L-tryptophan, pellitorine, phytol, elemicin, and 1,2,4-trimethoxyphenyl-5-aldehyde were isolated. The structures of the new compounds were elucidated using spectroscopic methods.
CONCLUSIONS:
These lignans inhibited nitric oxide production by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide and interferon-gamma.
Phytochemistry Letters, 2015, 13:200-205.
Aryltetralols from Holostylis reniformis and syntheses of lignan analogous.[Reference:
WebLink]
METHODS AND RESULTS:
Two new lignans, an aryltetralol and its methyl ether analogous, were isolated from Holostylis reniformis (Aristolochiaceae) together with Futokadsurin C and (−)-8′-epi-aristoligone. The latter was also obtained as an enantiomeric mixture by synthesis and was transformed into aryltetralols and aryltetralenes that were subjected to chiral-HPLC separations. The compound structures were determined by spectroscopic methods.
CONCLUSIONS:
Several of these lignans had their antiplasmodial activity (against Plasmodium falciparum, W2 clone, anti-HRPII) and toxicity to mammalian kidney cells (MDL50) evaluated. (−)-Cyclogalgravin and (−)-aristoligol exhibited activity (IC50 ～ 10.8 and 8.4 μM, respectively), the latter exhibited lower toxicity.
