Casegravol
Casegravol shows antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Chinese Medicine2019, 14(1)
Journal of Ginseng Research2024, 03.005.
J of Pharmaceutical Analysis2020, doi: 10.1016
Am J Chin Med.2022, 1-20.
J Ethnopharmacol.2017, 209:305-316
Korean J. Medicinal Crop Sci.2021, 29(1):45-50.
Industrial Crops and Products2019, 140:111612
J Applied Biological Chemistry2021, 64(2):185-192
Phytother Res.2022, 10.1002:ptr.7592.
Hum Exp Toxicol.2023, 42:9603271221145386.
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Biol Pharm Bull. 2004 Aug;27(8):1312-6.
Antiproliferative constituents in plants 14. Coumarins and acridone alkaloids from Boenninghausenia japonica NAKAI.[Pubmed:
15305045]
METHODS AND RESULTS:
The MeOH extracts of the ground part and the root of Boenninghausenia japonica NAKAI showed inhibitory activity against tumor cell growth. Fractionation of the extracts has resulted in isolation of 1,3-dihydroxy-4-(2'-hydroxy-3'-hydroxymethyl-3',4'-epoxy-butyl)-N-methylacridone, 1,3-dihydroxy-4-[(Z)-3'-hydroxy-3'-methyl-buten-1'-yl]-N-methylacridone, 3-(1',1'-dimethylallyl)-7-hydroxy-8-methoxy-2H-1-benzopyran-2-one, Casegravol, cis-Casegravol, and edgeworin in addition to 9 compounds reported from B. japonica and B. albiflora.
CONCLUSIONS:
The isolates from this plant and some related compounds were tested for antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.
Zhong Yao Cai. 2013 May;36(5):744-6.
Study on the chemical constituents from ethyl acetate extract of Micromelum falcatum.[Pubmed:
24218965]
To study the chemical constituents from ethyl acetate extract of Micromelum falcatum.
METHODS AND RESULTS:
The constituents were separated and purified by silica gel, Sephadex LH-20 and HPLC. Their structures were elucidated by spectral analysis (NMR, MS).
Ten compounds were isolated and identified as micropubescin (1), phebalosin (2), scopoletin (3), citrubuntin (4), thamnosmonin (5), hopeyhopin (6), arnottinin (7), Casegravol (8), 2-methoxy-5-hydroxy cinnamate (9), threo-syringoylglycerol (10).
CONCLUSIONS:
Compounds 1 - 10 are obtained from this plant for the first time.
