Murrayone
Murrayone can significantly inhibit the abnormal increase of platelet aggregation induced by ADP.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Wageningen University & Research2018, January 2018
LWT-Food Sci Technol2020, 109163
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Int J Mol Sci.2022, 23(21):13112.
J Sep Sci.2023, 46(16):e2300160.
Evid Based Complement Alternat Med.2021, 2021:8847358.
Chengdu University of Traditional Chinese Medicine2024, 4802935.
J Appl Pharm Sci.2022, 12(04):044-053
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Zhongguo Zhong Yao Za Zhi. 2014 Nov;39(22):4356-9.
Coumarins from Leonurus japonicus and their anti-platelet aggregative activity[Pubmed:
25850267]
Chemical constituents of Leonurus japonicus were isolated and purified by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, MCI, and Rp C18.
METHODS AND RESULTS:
Structures of the isolates were determined by spectroscopic analysis as 10 coumarins: bergapten (1), xanthotoxin (2), isopimpinellin (3), isogosferal (4), imperatorin (5), meransin hydrate(6), isomeranzin(7), Murrayone(8) , auraptenol(9), and osthol(10). In addition to compound 9, the others were isolated from the genus Leonurus for the first time.
CONCLUSIONS:
In the in vitro assay, compounds 4 and 8 significantly inhibited the abnormal increase of platelet aggregation induced by ADP.
