Cedrelopsin

Cedrelopsin
Product Name Cedrelopsin
CAS No.: 19397-28-5
Catalog No.: CFN89410
Molecular Formula: C15H16O4
Molecular Weight: 260.28 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Powder
Source: The trunk barks of Cedrelopsis grevei.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Cedrelopsin shows significant inhibition against A549 cells with IC50 values of 3.6-5.9 ug/mL.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Catalog No: CFN89410
    CAS No: 19397-28-5
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    Medicinal Chemistry Research, 2016, 25(3):466-472.
    Cytotoxic constituents of Oldenlandia umbellata and isolation of a new symmetrical coumarin dimer.[Reference: WebLink]
    Chemical investigation of HUM-E and HUM-B resulted in the isolation of a novel symmetrical coumarin dimer named oledicoumarin (1), together with eleven known compounds, hedyotiscone B (2), Cedrelopsin (3), pheophorbide A methyl ester (4), deacetyl asperuloside (5), scandoside methyl ester (6), asperulosidic acid (7), scandoside (8), nicotinic acid (9), 6α-hydroxy geniposide (10) anthragallol 1,2-dimethyl ether (11) and anthragallol 1,3-dimethyl ether (12).
    METHODS AND RESULTS:
    All compounds were isolated for the first time from O. umbellata except anthragallols. This is the foremost report exploring the presence of coumarin derivatives in O. umbellata. Testing of cytotoxicity of isolated constituents revealed that compounds 3, 4, 11 and 12 showed significant inhibition against A549 cells with IC50 values of 3.6–5.9 μg/mL. Compounds 4, 11 and 12 showed marked inhibitory effect against MDA-MB-231 cells (IC50 3.6–9.1 μg/mL). Compounds 4 (IC50 1.7 μg/mL) and 7 (IC50 6.1 μg/mL) were highly active against HT-29 cells.
    CONCLUSIONS:
    In summary, the less polar fraction of O. umbellata and its constituents were found to be cytotoxic.
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    Two new coumarins, 7-methoxy-5-prenylcoumarin (isoCedrelopsin) (1) and 3',4'-dihydrobraylin (2), were isolated from the trunk bark of Cedrelopsis grevei, along with five known coumarins, microfolicoumarin (6,7-dimethoxy-5-prenylcoumarin, (3), obliquin (4), 8-methoxyobliquin (5), aesculetin (6), Cedrelopsin (7) and scoparone (8).
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