Baldrinal
Baldrinal, valtrate, and acevaltrate are the quality control compounds of Valeriana jatamansi Jones. Baldrinal shows selective cytotoxicity against metastatic prostate cancer (PC-3M) and colon cancer (HCT-8) cell lines.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J of Apicultural Research2020, 10.1080
Nanjing University of Chinese Medicine2022, 345930.
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J Asian Nat Prod Res. 2015 May 14:1-7.
Three decomposition products of valepotriates from Valeriana jatamansi and their cytotoxic activity.[Pubmed:
25971678 ]
METHODS AND RESULTS:
Three new decomposition products of valepotriates, valtrals A-C (1-3), and two known products, Baldrinal and homoBaldrinal, are formed during the isolation procedure of the ethanol extract of the whole plants of Valeriana jatamansi. Their structures were determined by spectroscopic methods including IR, MS, 1D, and 2D NMR experiments.
CONCLUSIONS:
Compounds 1-3 showed selective cytotoxicity against metastatic prostate cancer (PC-3M) and colon cancer (HCT-8) cell lines.
J Sep Sci. 2017 May;40(9):1906-19.
Flexible and powerful strategy for qualitative and quantitative analysis of valepotriates in Valeriana jatamansi Jones using high-performance liquid chromatography with linear ion trap Orbitrap mass spectrometry.[Pubmed:
28296152 ]
Valeriana jatamansi Jones is an important medicinal plant and its quality is closely related to its region of origin. In the current study, we utilized a flexible and powerful strategy for comprehensive evaluation of the quality diversity for 15 regions in China.
METHODS AND RESULTS:
The method was based on a hybrid linear ion trap-Orbitrap mass spectrometry platform. For structure characterization, fragmentation patterns were detected by analyzing a series of standard compounds using data dependent multistage mass spectrometry acquisition. A fragment ion database for valepotriates was established, and the acquired data were high throughput filtered by fragment ion search for compound identification. For quantitative purposes, we normalized the mass spectrometry data of 15 samples using SIEVE 2.0 and the differences in composition were analyzed using principal component analysis combined with hierarchical clustering analysis. The results identified a total of 92 compounds from Valeriana jatamansi Jones. Samples from Dali, Kunming, and Baoshan have better qualities and concentrations of the main active constituents.
To verify our strategy, we compared the valtrate, acevaltrate, and Baldrinal contents using high-performance liquid chromatography with diode array detector.
CONCLUSIONS:
We developed and validated a comprehensive qualitative and quantitative analytical method to achieve quality control of Valeriana jatamansi Jones.
Arch Pharm Res. 2005 Oct;28(10):1161-3.
11-Methoxyviburtinal, a new iridoid from Valeriana jatamansi.[Pubmed:
16276973]
METHODS AND RESULTS:
Five compounds of iridoids, lignan and phenylpropanoid glycosides were isolated from the roots of Valeriana jatamansi by column chromatography. Their structures were elucidated as 11-methoxyviburtinal (1), Baldrinal (2), prinsepiol-4-omicron-beta-D-glucoside (3), coniferin (4), and hexacosanic acid (5) by spectroscopic analysis.
CONCLUSIONS:
11-Methoxyviburtinal was a new compound, and others were isolated from the plant for the first time.
