Homobaldrinal
Homobaldrinal has low toxic activity. It has genotoxic activity in the Salmonella/microsome test and the SOS-chromotest.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
bioRxiv - Biochemistry2023, 548213.
Curr Issues Mol Biol.2023, 45(2):1587-1600.
Phytomedicine.2022, 102:154183.
Oncotarget.2016, 8(51):88386-88400
Foods.2023, 12(6):1130.
Journal of Food Quality2022, P:13, 6256310.
Nutrients.2017, 10(1)
J Nat Prod.2021, 84(9):2544-2553.
Mol Pharm.2017, 14(9):3164-3177
Molecules.2023, 28(3):958.
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Mutat Res. 1986 Jan-Feb;169(1-2):23-7.
Bacterial mutagenicity of the tranquilizing constituents of Valerianaceae roots.[Pubmed:
3511364 ]
The valepotriates valtrate/isovaltrate and dihydrovaltrate are considered to be the main tranquilizing constituents of drugs derived from the roots of several Valerianaceae.
METHODS AND RESULTS:
The decomposition products of valtrate and isovaltrate include the metabolites baldrinal and Homobaldrinal, respectively, whereas the decomposition products of dihydrovaltrate do not include baldrinal-like metabolites. Purified valtrate/isovaltrate, dihydrovaltrate, baldrinal and Homobaldrinal were investigated for their genotoxic activity in the Salmonella/microsome test and the SOS-chromotest.
CONCLUSIONS:
The valepotriates developed mutagenic activity in these test systems only in the presence of S9 mix, whereas both baldrinals showed mutagenic effects in both tests with and without metabolic activation.
Phytomedicine. 1998 May;5(3):219-25.
Cytotoxic potential of valerian constituents and valerian tinctures.[Pubmed:
23195845]
METHODS AND RESULTS:
The monoene type valepotriates (didrovaltrate and isovaleroxyhydroxydidrovaltrate) were 2- to 3-fold less toxic. Baldrinal and Homobaldrinal, decomposition products of valepotriates, were 10- to 30-fold less toxic than their parent compounds.
