Alpha-Angelica lactone
Alpha-Angelica lactone has cardiotonic activity, may exert their effects by providing an increased contraction-dependent calcium pool to be released upon systolic depolarization. Alpha-Angelicalactone can induce increased glutathione (GSH) S-transferase activity in the liver and small intestine in female ICR/Ha mice, it is an inhibitor of chemical carcinogenesis.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Natl Cancer Inst. 1982 Mar;68(3):493-6.
Glutathione S-transferase activity: enhancement by compounds inhibiting chemical carcinogenesis and by dietary constituents.[Pubmed:
6278195]
Benzyl isothiocyanate, beta-naphthoflavone, coumarin, Alpha-Angelica lactone, disulfiram, indole-3-carbinol and indole-3-acetonitrile induced increased glutathione (GSH) S-transferase activity in the liver and small intestine in female ICR/Ha mice.
METHODS AND RESULTS:
All seven compounds are inhibitors of chemical carcinogenesis. In additional work, several dietary constituents increased GSH S-transferase activity. Consumption of diets containing dried powdered preparations of brussels sprouts, cabbage, coffee beans, or tea leaves resulted in increased GSH S-transferase activity. Mice fed an unrefined diet (Purina Rat Chow) had a higher GSH S-transferase activity than those fed a semipurified diet.
CONCLUSIONS:
The results of the present study indicated that the composition of the diet can alter the activity of an important enzyme system having the capacity to detoxify chemical carcinogens.
J Clin Invest. 1969 Feb;48(2):229-34.
The influence of ouabain and alpha angelica lactone on calcium metabolism of dog cardiac microsomes.[Pubmed:
4236805]
The influence of ouabain and Alpha-Angelica lactone on (45)calcium accumulation in cardiac microsomes was studied.
METHODS AND RESULTS:
Calcium binding (accumulation in the absence of excess oxalate or phosphate) was augmented by both ouabain and Alpha-Angelica lactone in the presence of adenosine triphosphate (ATP) but unaffected in its absence. Calcium turnover (defined as the change in (45)Ca(++) bound to the microsomes after the specific activity is changed) was studied to determine if the augmented bound pool was freely exchangeable at equilibrium. Ouabain and Alpha-Angelica lactone augmented calcium turnover in both the presence and absence of ATP. Calcium-stimulated ATPase was increased by both agents.
CONCLUSIONS:
It is proposed that these two unsaturated lactones, with known cardiotonic activity, may exert their effects by providing an increased contraction-dependent calcium pool to be released upon systolic depolarization.
Org Lett. 2011 Jun 17;13(12):3056-9.
Catalytic asymmetric vinylogous Mannich-type (AVM) reaction of nonactivated α-angelica lactone.[Pubmed:
21595425]
A direct highly diastereo- and enantioselective asymmetric vinylogous Mannich-type (AVM) reaction of aldimines with nonactivated natural Alpha-Angelica lactone has been successfully developed. It was demonstrated that the nonactivated natural Alpha-Angelica lactone is a useful vinylogous nucleophile to give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives. The N,N'-dioxide L2-Sc(III) complex is efficient toward the obtention of a range of corresponding products with adjacent quaternary and tertiary stereocenters in excellent dr and ee values.
