Bakkenolide D
Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have obvious anti-histamine activities.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Academic Journal of Second Military Medical University, 2006, 27(11):1210-1213.
Chemical constituents in root of Petasites tricholobus Franch. and their anti-inflammatory activity[Reference:
WebLink]
To study the chemical constituents in the root of Petasites tricholobus Franch, and evaluate their anti-inflammatory activity.
METHODS AND RESULTS:
The primary extraction was done with 95% ethanol and subsequently with other agents including ethyl acetate. The compounds extracted with ethyl acetate were isolated by silica gel column chromatography and purified by means of recrystallization. The structures of the compounds were elucidated by employing chemical and spectral methods. The anti-inflammatory activities of the compounds were evaluated through their inhibitory effect on the trachea contraction of guinea pig induced by histamine in vitro. Six compounds were isolated from the root of Petasites tricholobus Franch., namely, homofukinolide(1), bakkenolide B(2), stigmasterol(3), and β-sitosterol(4), Bakkenolide D(5), and β-sitosterol-3-O-β-D-glucopyranoside(6). Bakkenolide B and Bakkenolide D demonstrated inhibitory effect on the trachea contraction induced by histamine in vitro.
CONCLUSIONS:
Homofukinolide, β-sitosterol, and β-sitosterol-3-O-β-D-glucopyranoside are isolated for the first time from Petasites tricholobus Franch. Bakkenolide B and Bakkenolide D have obvious anti-histamine activities.
Phytother Res. 2011 Jan;25(1):116-21. doi: 10.1002/ptr.3237.
Anti-allergic effects of total bakkenolides from Petasites tricholobus in ovalbumin-sensitized rats.[Pubmed:
20625987]
The anti-allergic effect of total bakkenolides from the rhizome of Petasites tricholobus (BAPT) was evaluated in an ovalbumin-induced allergic rhinitis model in male Wistar rats.
METHODS AND RESULTS:
The major components of the bakkenolide fraction are Bakkenolide D, bakkenolide B, bakkenolide IIIa and bakkenolide IVa, which account for 60.04% of the total. The rats were treated with 40 mg/kg, 20 mg/kg, 10 mg/kg or 5 mg/kg BAPT, and 0.942 mg/kg loratadine and 0.5% gum tragacanth were used as positive and negative controls, respectively. The frequency of nose rubbing and sneezing was observed, the number of eosinophils infiltrating into the nasal tissue was counted, and serum levels of IL-4 and histamine were determined by ELISA.
CONCLUSIONS:
The results showed that BAPT had a beneficial effect on allergic rhinitis in ovalbumin-sensitized Wistar rats, which was evidenced by a significant decrease in the frequency of sneezing, the number of eosinophils infiltrating into the nasal tissue, and the serum levels of IL-4 and histamine. BAPT may therefore be a potential antiallergic drug.
Biomed Chromatogr. 2013 Sep;27(9):1200-7.
LC-MS/MS determination of bakkenolide D in rats plasma and its application in pharmacokinetic studies.[Pubmed:
23723093]
A sensitive and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for determination of Bakkenolide D (BD), which was further applied to assess the pharmacokinetics of Bakkenolide D.
METHODS AND RESULTS:
In the LC-MS/MS method, the multiple reaction monitoring mode was used and columbianadin was chosen as internal standard. The method was validated over the range of 1-800 ng/mL with a determination coefficient >0.999. The lower limit of quantification was 1 ng/mL in plasma. The intra- and inter-day accuracies for Bakkenolide D were 91-113 and 100-104%, respectively, and the inter-day precision was <15%. After a single oral dose of 10 mg/kg of Bakkenolide D, the mean peak plasma concentration of Bakkenolide D was 10.1 ± 9.8 ng/mL at 2 h. The area under the plasma concentration-time curve (AUC0-24 h ) was 72.1 ± 8.59 h ng/mL, and the elimination half-life (T1/2 ) was 11.8 ± 1.9 h. In case of intravenous administration of Bakkenolide D at a dosage of 1 mg/kg, the AUC0-24 h was 281 ± 98.4 h⋅ng/mL, and the T1/2 was 8.79 ± 0.63 h.
CONCLUSIONS:
Based on these results, the oral bioavailability of Bakkenolide D in rats at 10 mg/kg is 2.57%.
