Bakkenolide A

Bakkenolide A
Product Name Bakkenolide A
CAS No.: 19906-72-0
Catalog No.: CFN98579
Molecular Formula: C15H22O2
Molecular Weight: 234.34 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Powder
Targets: HDAC | IkB | IL Receptor | Caspase | TNF-α | PI3K | Akt | GSK-3 | IKK
Source: The herbs of Petasites japonicus F. Schmidt
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $318/5mg
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Food Research2021, 5(1):65-71
  • Toxins (Basel).2020, 12(4):210.
  • J Biochem Mol Toxicol.2017, 31(9)
  • Phytochemistry.2017, 141:162-170
  • Antioxidants (Basel).2020, 9(4):326.
  • Acta Agriculturae Scandinavica2015, 381-383
  • J Chromatogr B Analyt Technol Biomed Life Sci.2022, 1203:123307.
  • Biomolecules.2021, 11(10):1537.
  • Phytomedicine.2019, 59:152785
  • Pharmacogn J.2022, 14(2):350-357
  • Bakkenolide A

    Catalog No: CFN98579
    CAS No: 19906-72-0
    Price: $318/5mg
    Bakkenolide III

    Catalog No: CFN96942
    CAS No: 24909-95-3
    Price: Inquiry(manager@chemfaces.com)
    1-Oxobakkenolide S

    Catalog No: CFN96812
    CAS No: 18456-02-5
    Price: Inquiry(manager@chemfaces.com)
    Bakkenolide B

    Catalog No: CFN96902
    CAS No: 18455-98-6
    Price: Inquiry(manager@chemfaces.com)
    Bakkenolide IIIa

    Catalog No: CFN89054
    CAS No: 915289-60-0
    Price: Inquiry(manager@chemfaces.com)
    Bakkenolide D

    Catalog No: CFN90795
    CAS No: 18456-03-6
    Price: Inquiry(manager@chemfaces.com)
    Bakkenolide Db

    Catalog No: CFN96815
    CAS No: 226711-23-5
    Price: Inquiry(manager@chemfaces.com)
    Glochicoccin D

    Catalog No: CFN97495
    CAS No: 927812-23-5
    Price: Inquiry(manager@chemfaces.com)
    Muscone

    Catalog No: CFN99518
    CAS No: 541-91-3
    Price: $30/20mg
    Officinaruminane B

    Catalog No: CFN92687
    CAS No: 1246282-67-6
    Price: Inquiry(manager@chemfaces.com)
    J.Appl. Entomol.,2010,107(1-5):524-9.
    Antifeedant and growth inhibitory effects of bakkenolide-A and other sesquiterpene lactones on the variegated cutworm, Peridroma saucia Huebner (Lep., Noctuidae). [Reference: WebLink]

    METHODS AND RESULTS:
    When added to artificial diets, the sesquiterpene lactone Bakkenolide A deterred feeding of neonate variegated cutworms in a choice test, and inhibited larval growth in a no-choice bioassay. In both bioassays, Bakkenolide A was more active against this polyphagous pest than several other sesquiterpene lactones previously shown to be active against other insects. In the choice test, older larvae (second instar) were found to be less sensitive to the antifeedant effect of Bakkenolide A than younger ones (first instar). Bakkenolide A also reduced larval growth and survival of second instar larvae when applied topically.
    CONCLUSIONS:
    Bioactivity of Bakkenolide A via topical application was also greater than that of other sesquiterpene lactones tested.
    Biomed. Pharmacother.,2016 Oct;83:958-66.
    Bakkenolide A inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways.[Pubmed: 27522258 ]
    Leukemia has been the third type of cancer killing many people across the world. Bakkenolide A (Bak), extracted from Petasites tricholobus, has been suggested to against cancer and display protective effects on inflammatory cytokines formation. And increasing evidences suggest that histone deacetylase 3 (HDAC3) plays vital roles in cancer formation and persistence via cell death, apoptosis and inflammation. But the function of Bakkenolide A in regulating leukemia is not understood yet, particularly via HDAC3.
    METHODS AND RESULTS:
    Here, we found that HDAC3 is up-regulated in clinical samples of leukemia compared with adjacent normal tissues. Then the expression of HDAC3 was knocked down via RNA interference in K562 cells. And inhibition of HDAC3 expression is able to improve leukemia invasion, migration and proliferation. Further, we also found HDAC3 bound to IκBα, affecting subsequent inflammation response. Moreover, Bakkenolide A was found to inhibit inflammation, induce apoptosis and cell death in leukemia cells via PI3K-regulated signaling pathway, down-regulating IKKs expression and suppressing in proinflammatory cytokines of IL-1β, IL-18 and TNF-α. Up-regulation of Caspase3/7 was observed in cells of HDAC3-knockdown and Bakkenolide A treatment, inducing leukemia cell apoptosis. Also, the expression of Akt and GSK were activated by HDAC3-knockdown and Bakkenolide A-treatment.
    CONCLUSIONS:
    Thus, these results indicated that Bakkenolide A-mediated HDAC3 sensitization in leukemia cells seem to be associated with activation of effector IKKs, Akt/GSK, and caspases through induction of the PI3K pathway, leading to inflammation, cell death, and apoptosis.
    J Mass Spectrom. 2012 Aug;47(8):962-8.
    Determination of bakkenolide A in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study.[Pubmed: 22899504]

    METHODS AND RESULTS:
    A sensitive rapid analytical method was established and validated to determine the Bakkenolide A (BA) in rat plasma. This method was further applied to assess the pharmacokinetics of Bakkenolide A in rats receiving a single dose of Bakkenolide A. Intra- and inter-day accuracies for Bakkenolide A were 93-112% and 103-104%, respectively, and the inter-day precision was less than 15%. After a single oral dose of 20 mg/kg of Bakkenolide A, the mean peak plasma concentration (C(max) ) of Bakkenolide A was 234.7 ± 161 ng/mL at 0.25 h. The area under the plasma concentration-time curve (AUC(0-24 h) ) was 535.8 ± 223.7 h·ng/mL, and the elimination half-life (T(1/2) ) was 5.0 ± 0.36 h. In case of intravenous administration of Bakkenolide A at a dosage of 2 mg/kg, the area under the plasma concentration-time curve (AUC(0-24 h) ) was 342 ± 98 h⋅ng/mL, and the elimination half-life (T(1/2) ) was 5.8 ± 0.7 h.
    CONCLUSIONS:
    Based on the results, the oral bioavailability of Bakkenolide A in rats at 20 mg/kg is 15.7%.
    Ampelopsin G

    Catalog No: CFN95148
    CAS No: 151487-09-1
    Price: $318/5mg
    Astin C

    Catalog No: CFN95189
    CAS No: 148057-23-2
    Price: $318/10mg
    6'-Feruloylnodakenin

    Catalog No: CFN95202
    CAS No: 131623-14-8
    Price: $318/10mg
    Licoflavanone

    Catalog No: CFN95213
    CAS No: 119240-82-3
    Price: $413/5mg
    Ginsenoside Rd2 (Quinquenoside L10)

    Catalog No: CFN95231
    CAS No: 83480-64-2
    Price: $318/10mg
    Phloretin 3',5'-Di-C-glucoside

    Catalog No: CFN95306
    CAS No: 357401-40-2
    Price: $318/10mg
    10-O-trans-p-Feruloylscandoside

    Catalog No: CFN95392
    CAS No: 1428268-72-7
    Price: $318/10mg
    Caffeoylcalleryanin

    Catalog No: CFN95532
    CAS No: 20300-49-6
    Price: $318/10mg
    8-Hydroxy-5,7-dimethoxyflavanone

    Catalog No: CFN95580
    CAS No: 201230-40-2
    Price: $318/5mg
    11-Keto-ganoderic acid DM

    Catalog No: CFN95593
    CAS No: N/A
    Price: $413/5mg