Apigenin 5-O-beta-D-glucopyranoside
Apigenin 5-O-beta-D-glucopyranoside has inhibitory activity against the enzyme yeast a-glucosidase, withthe IC50 value of 287.12 muM.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Phytotherapy Research. 2006 July;20(7):610–613.
Isolation of flavonoids, a biscoumarin and an amide from the flower buds of Daphne genkwa and the evaluation of their anti-complement activity[Reference:
WebLink]
As part of an ongoing study aimed at identifying the anti-complement active compound from the flower buds of Daphne genkwa, ten flavonoids, one biscoumarin and one amide were isolated.
METHODS AND RESULTS:
Their structures were identified from spectroscopic and physicochemical data as genkwanin 5-O-β-d-primveroside (1), apigenin 7-O-β-d-glucuronide (2), genkwanin 5-O-β-d-glucopyranoside (3), Apigenin 5-O-beta-D-glucopyranoside (4), genkwanin (5), apigenin (6), luteolin 7-methyl ether (7), luteolin (8), daphnoretin (9), velutin (10), 7-methoxyacacetin (11) and aurantiamide acetate (12). Among them, compounds 9, 10 and 12 were isolated from this plant for the first time. The anti-complement activity of these compounds was tested against the classical pathway of the complement system.
CONCLUSIONS:
Among the compounds, daphnoretin (9) exhibited significant anti-complement activity with an IC50 value of 11.4 µm, whereas the other compounds were not active in the assay.
Phytochem. Lett., 2013, 6(4):614-9.
α-Glucosidase inhibitory constituents from Chrozophora plicata[Reference:
WebLink]
METHODS AND RESULTS:
Five new secondary metabolites have been isolated from Chrozophora plicata including an acacetin derivative (1), three pyrrole alkaloids plicatanins A–C (2-4 resp) and the bilactone plicatanone (5). Together with these compounds, the known compounds, β-sitosterol (6), methyl p-coumarate (7), 4-hydroxyphenylacetic acid (8), succinic acid (9), speranberculatine A (10), β-sitosterol-3-O-β- d -glucopyranoside (11) and a Apigenin 5-O-beta-D-glucopyranoside (12) have also been isolated. The structures of isolates 1-12 were established by 1D (1 H,13 C) and 2D NMR (HMQC, HMBC, COSY) spectroscopy and mass spectrometry (EIMS, HREIMS, FABMS, HRFABMS). The structure of plicatanin A (3) was further confirmed through single crystal X-ray technique. Compounds 1-12 were evaluated for their inhibitory activity against the enzyme yeast α -glucosidase.
CONCLUSIONS:
The compound 4 was found to be most potent with IC 50 value 27.802uM.
