Anisofolin A

Anisofolin A
Product Name Anisofolin A
CAS No.: 83529-71-9
Catalog No.: CFN97327
Molecular Formula: C39H32O14
Molecular Weight: 724.7 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Targets: Antifection
Source: The herbs of Leonurus japonicus
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price:
Anisofolin A has promising antimalarial activity (IC50 4.39 ± 0.25 uM). It has promising antimycobacterium activity [IC50 4.50 ± 0.75 uM (3.31 ug/mL)] against M. tuberculosis H37Ra and at 100 ug/mL, shows 55.6 % inhibition of M. bovis.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    METHODS AND RESULTS:
    A phytochemical investigation of the acetone extract from the aerial parts of Leucas mollissima afforded one new (−)epi-marmelo lactone, (2 S, 4R, 6 S)-2,6-dimethyl-6 hydroxy-7-ene-4-olide (1), along with five known compounds, schensianol A (2), vanillin (3), β-hydroxy propiovanillone (4), lanost-9(11),25-diene-3β,24β-diol (5), and lanost-9(11),23E(24)-diene-3β,25-diol (6). Similarly, an investigation of the methanol extract of the aerial parts of L. mollissima resulted in the isolation of three known compounds, (+)-syringaresinol (7), Anisofolin A (8), and apigenin 7-O-β-D(− 6′′-p-E-coumaroyl)-glucoside (9). Structure elucidation of the isolated compounds was carried out using detailed analysis of 1D and 2D nuclear magnetic resonance. All compounds were evaluated for antimalarial activity against Plasmodium falciparum (3D7) and for antimycobacterium activity against Mycobacterium tuberculosis H37Ra and Mycobacterium bovis.
    CONCLUSIONS:
    Compound 8 was found to have promising antimalarial activity (IC50 4.39 ± 0.25 μM), promising antimycobacterium activity [IC50 4.50 ± 0.75 μM (3.31 μg/mL)] against M. tuberculosis H37Ra and at 100 μg/mL, showed 55.6 % inhibition of M. bovis. Compound 9 showed moderate inhibition of P. falciparum growth (35 % inhibition at 10 μM) with respect to the positive control atovaquone and 67.4 % inhibition against M. bovis at 100 μg/mL with respect to the positive control rifampicin.
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    METHODS AND RESULTS:
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