7-Methoxy-1-naphthylacetonitrile
7-Methoxy-1-naphthyl-acetonitrile is an important intermediate in the preparation of anti-depression drugs.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Physical Testing & Chemical Analysis, 2009 , 45 (6) :654-5.
HPLC Determination of a Pharmaceutical Intermediate 7-Methoxy-1-naphthyl-Acetonitrile[Reference:
WebLink]
HPLC was applied to the determination of 7-Methoxy-1-naphthylacetonitrile(MONAN),which is an important intermediate in the preparation of anti-depression drugs.
METHODS AND RESULTS:
The Diamonsil C18 chromatographic column(250 mm×4.6 mm,5 μm) was used as stationary phase for separation of MONAN from co-existing by-products and impurities at column temperature of 20 ℃.A mixture of methanol and H2O(80+20) was used as mobile phase with flow-rate of 0.8 mL·min-1.UV-detection was made at the wavelength of 231 nm.Volume of sample solution introduction was 20 μL.Linear relationship between values of peak area and mass concentration of MONAN was obtained in the range of 2-48 mg·L-1.Detection limit(3S/N) found for the method was 105 μg·L-1.
Precision and recovery were tested at the concentration level of 40.0 mg·L-1 of MONAN for 6 determinations,value of RSD and average recovery found were 0.034% and 99.7% respectively.
