5,8-Epidioxyergosta-6,9(11),22-trien-3-ol
5,8-Epidioxyergosta-6,9(11),22-trien-3-olshows cytotoxic activity, it was selectively cytotoxic to cancer cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Natural Product Research, 2016, 30(16):1-4.
Cytotoxic constituents of Lasiosphaera fenzlii on different cell lines and the synergistic effects with paclitaxel.[Reference:
WebLink]
METHODS AND RESULTS:
The fruit body of Lasiosphaera fenzlii was found to show cytotoxicity on cancer cells during a preliminary screening. Repeated column chromatography of the fungal methanol extract resulted in the isolation of six compounds identified as 5α,8α-epidioxy-ergosta-6,22-dien-3β-ol (5,8-Epidioxyergosta-6,9(11),22-trien-3-ol,1), 5α,8α-epidioxy-ergosta-6,9(11),22-trien-3β-ol (2), 5α-ergosta-7,22-dien-3β-ol (3), 5α-ergosta-7,22-dien-3-one (4), ergosta-7,22-dien-3β,5α,6β-triol (5) and 6-dihydroxy-2,3-dihydro-1H-isoindol-1-one (6).
CONCLUSIONS:
The two peroxide compounds, 1 and 2, showed cytotoxic activity and compound 1 was selectively cytotoxic to cancer cells. Furthermore, compound 1 synergised the cytotoxicity of paclitaxel on Hela cells by increasing intracellular accumulation of paclitaxel in cancer cells but not in normal cells.
Phytochemistry,1993,32(6):1549-1551
Steroids of formosan Ganoderma amboinense[Reference:
WebLink]
METHODS AND RESULTS:
A new polyhydroxyl steroid and a new lanostanoid, named ganoderic acid AM1, together with the known steroids ergosta-7,22-dien-3β-ol, ergosta-7,22-dien-3β-yl linoleate, ergosterol peroxide, ergosta-7,22-dien-3β-yl palmitate, 2 β,3 α,9 α-trihydroxyergosta-7,22-diene,
5α, 8α-epidioxyergosta-6,9(11),22-trien-3β-ol(5,8-Epidioxyergosta-6,9(11),22-trien-3-ol
), and lucidone A have been isolated from Formosan Ganoderma amboinense.
CONCLUSIONS:
The new steroid and ganoderic acid AM 1 were characterized as 2β-methoxyl-3α, 9α-dihydroxyergosta-7,22-diene and 3β-hydroxy-7,11,15,23-tetraoxo- lanosta-8-en-26-oic acid, respectively.
