Licoarylcoumarin

Licoarylcoumarin
Product Name Licoarylcoumarin
CAS No.: 125709-31-1
Catalog No.: CFN95072
Molecular Formula: C21H20O6
Molecular Weight: 368.4 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Powder
Targets: cAMP | HIV | Antifection
Source: The roots of Glycyrrhiza uralensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $413/5mg
Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Oncotarget.2017, 8(53):90925-90947
  • Molecules.2019, 24(2):329
  • Molecular & Cellular Toxicology2017, 13(3):271-278
  • Sci Rep.2018, 8:15059
  • Front Pharmacol.2018, 9:236
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Int Immunopharmacol.2019, 71:361-371
  • Molecules.2019, 24(7):E1290
  • Sci Rep. 2018, 10590
  • Asian Journal of Chemistry2014, 26(22):7811-7816
  • Wedelolactone

    Catalog No: CFN98857
    CAS No: 524-12-9
    Price: $128/20mg
    Isodemethylwedelolacton

    Catalog No: CFN90625
    CAS No: 350681-33-3
    Price: $268/10mg
    Psoralidin

    Catalog No: CFN98592
    CAS No: 18642-23-4
    Price: $118/20mg
    Neoglycyrol

    Catalog No: CFN90792
    CAS No: 23013-84-5
    Price: $398/10mg
    Glycycoumarin

    Catalog No: CFN89408
    CAS No: 94805-82-0
    Price: $268/10mg
    Glycyrin

    Catalog No: CFN89404
    CAS No: 66056-18-6
    Price: $368/5mg
    Licopyranocoumarin

    Catalog No: CFN92918
    CAS No: 117038-80-9
    Price: Inquiry(manager@chemfaces.com)
    Licoarylcoumarin

    Catalog No: CFN95072
    CAS No: 125709-31-1
    Price: $413/5mg
    Coumestrol

    Catalog No: CFN96040
    CAS No: 479-13-0
    Price: $178/10mg
    4'-O-Methylcoumestrol

    Catalog No: CFN96922
    CAS No: 1690-62-6
    Price: Inquiry(manager@chemfaces.com)
    Molecules. 2014 Mar 28;19(4):3883-97.
    Structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant Enterococcus species.[Pubmed: 24686577]
    Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive effects on the oxacillin resistance of MRSA, we further investigated effectiveness of licorice constituents on vancomycin-resistant Enterococcus (VRE) bacteria, and purified 32 phenolic compounds.
    METHODS AND RESULTS:
    Two flavonoids among them were characterized structurally, and identified their structures as demethylglycyrol (31) and 5,7-di-O-methylluteone (32), respectively. Examination of antibacterial effects of licorice phenolics showed that 3-arylcoumarins such as Licoarylcoumarin (9) and glycycoumarin (26), and 2-arylcoumarones such as gancaonin I (17), have moderate to potent antibacterial effects on the VRE strains used in this study.
    Chem Pharm Bull (Tokyo). 1989 Nov;37(11):3005-9.
    Phenolic constituents of licorice. II. Structures of licopyranocoumarin, licoarylcoumarin and glisoflavone, and inhibitory effects of licorice phenolics on xanthine oxidase.[Pubmed: 2632045]

    METHODS AND RESULTS:
    An anti-HIV (human immunodeficiency virus) phenolic constituent, licopyranocoumarin (4), and two other new phenolics named Licoarylcoumarin (5) and glisoflavone (6) were isolated from Si-pei licorice (a commercial licorice; root and stolon of Glycyrrhiza sp. from the north-western region of China) using droplet countercurrent chromatography and centrifugal partition chromatography, and their structures were assigned based on chemical and spectroscopic data. Kaempferol 3-O-methyl ether (7) and licocoumarone (8) were also isolated from the licorice.
    CONCLUSIONS:
    The inhibitory effects of ten licorice phenolics on xanthine oxidase were examined. Licochalcone B (1), glycyrrhisoflavone (2), 8 and licochalcone A (19) showed 50% inhibition at the concentration of 1.3-5.6 x 10(-5) M.
    Chem Pharm Bull (Tokyo). 1991 Apr;39(4):930-3.
    Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by flavonoids from licorice roots and 4-arylcoumarins.[Pubmed: 1654220]
    Isoliquiritigenin, glabridin, Licoarylcoumarin and licoricidin were identified as strong inhibitors of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase in waste materials which were obtained during the industrial extraction of glycyrrhizin from licorice roots.
    METHODS AND RESULTS:
    The structure-activity relationships of 12 flavonoids from licorice roots and 34 4-arylcoumarins were studied. In 4-arylcoumarins, 5,7-dihydroxy derivatives were generally highly inhibitory towards cAMP phosphodiesterase.
    2',4'-Dihydroxy-6'-methoxyacetophenone

    Catalog No: CFN98488
    CAS No: 3602-54-8
    Price: $100/5mg
    Jaceosidin

    Catalog No: CFN90386
    CAS No: 18085-97-7
    Price: $198/20mg
    Glychionide A

    Catalog No: CFN92280
    CAS No: 119152-50-0
    Price: $318/5mg
    Piplartine

    Catalog No: CFN96137
    CAS No: 20069-09-4
    Price: $100/20mg
    Aristolochic acid D

    Catalog No: CFN90783
    CAS No: 17413-38-6
    Price: $348/10mg
    Alloisoimperatorin

    Catalog No: CFN95012
    CAS No: 35214-83-6
    Price: $338/5mg
    (R)-Reticuline

    Catalog No: CFN95013
    CAS No: 3968-19-2
    Price: $338/10mg
    7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (DPHB)

    Catalog No: CFN95139
    CAS No: 79559-60-7
    Price: $268/20mg
    Pueroside B

    Catalog No: CFN95141
    CAS No: 100692-54-4
    Price: $288/10mg
    Leachianol F

    Catalog No: CFN95147
    CAS No: 164123-50-6
    Price: $318/5mg