5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA)
5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA) is a pancreatic lipase inhibitor, it shows antihyperlipidemic activity.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Agronomy2023, 13(6), 1435.
Int J Mol Sci.2023, 24(4):3682.
Plants (Basel).2023, 12(22):3877.
J Ethnopharmacol.2020, 260:112988.
Nutrients.2018, 10(12):E1998
Front Pharmacol.2024, 15:1439079.
Int Immunopharmacol.2019, 71:361-371
Anticancer Res.2021, 41(3):1357-1364.
Evid Based Complement Alternat Med.2016, 2016:4357656
Front Pharmacol.2022, 13:806869.
Related and Featured Products
7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (DPHB)
Catalog No: CFN95139
CAS No: 79559-60-7
Price: $268/20mg
Alnustone
Catalog No: CFN90620
CAS No: 33457-62-4
Price: $50/20mg
1,7-Diphenyl-5-hydroxy-4,6-hepten-3-one
Catalog No: CFN95171
CAS No: 87095-77-0
Price: $318/10mg
(R)-5-Hydroxy-1,7-diphenyl-3-heptanone
Catalog No: CFN92684
CAS No: 100761-20-4
Price: $318/10mg
5-Hydroxy-1-(4-hydroxyphenyl)-7-phenyl-3-heptanone (AO 2210)
Catalog No: CFN95137
CAS No: 105955-04-2
Price: $318/10mg
Yashabushidiol A
Catalog No: CFN95934
CAS No: 52393-53-0
Price: $318/5mg
(3S,5S,E)-1,7-Diphenylhept-1-ene-3,5-diol
Catalog No: CFN95195
CAS No: 87095-75-8
Price: $318/5mg
(3R,5S,E)-1,7-Diphenylhept-1-ene-3,5-diol
Catalog No: CFN95227
CAS No: 232261-31-3
Price: $318/5mg
5-Hydroxy-1,7-diphenyl-6-hepten-3-one
Catalog No: CFN97433
CAS No: 87095-74-7
Price: $100/20mg
5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA)
Catalog No: CFN95135
CAS No: 79559-61-8
Price: $268/20mg
Biol Pharm Bull. 2004 Jan;27(1):138-40.
5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone: a pancreatic lipase inhibitor isolated from Alpinia officinarum.[Pubmed:
14709919 ]
METHODS AND RESULTS:
A pancreatic lipase inhibitor, 5-hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (HPH)[5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA)
], from the rhizome of Alpinia officinarum (AO) was isolated and its antihyperlipidemic activity was measured. HPH inhibited a pancreatic lipase with an IC(50) value of 1.5 mg/ml (triolein as a substrate). HPH significantly lowered the serum TG level in corn oil feeding-induced triglyceridemic mice, and reduced serum triglyceride (TG) and cholesterol in Triton WR-1339-induced hyperlipidemic mice. However, HPH did not show hypolipidemic activity in high cholesterol diet-induced hyperlipidemic mice.
CONCLUSIONS:
Based on these findings, we propose that PL inhibitors may be effective as hypolipidemic agents.
