3alpha-dihydrocadambine
3alpha-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Eur J Pharmacol.2021, 899:174010.
PLoS One.2017, 12(8):e0181191
Biomedicines.2024, 12(3):495.
Sci Rep.2019, 9(1):18080
Anal Bioanal Chem. 2016, 408(15)
Microb Biotechnol.2021, 14(5):2009-2024.
Applied Biological Chemistry2022, 71:s13765-022-00743-5.
ACS Pharmacol. Transl. Sci.2022, 5,7,479-490
Molecules2022, 27(9):2613.
Comp. & Mathematical Methods in Med.2022, 5475559.
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Planta Med. 1985 Oct;51(5):424-7.
Hypotensive action of 3alpha-dihydrocadambine, an indole alkaloid glycoside of uncaria hooks1.[Pubmed:
17342601]
3alpha-dihydrocadambine exhibited dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats. Its activity was much stronger and longer-lasting than that of rhynchophylline. In anesthetized dogs, it caused dilation of the vertebral, femoral and common carotid arteries, and had almost no effect on the coronary artery, whereas it had almost no significant activity in isolated canine arterial strip preparations.
Chem Pharm Bull (Tokyo). 2003 Feb;51(2):232-3.
Gluco-indole alkaloids from Nauclea cadamba in Thailand and transformation of 3 alpha-dihydrocadambine into the indolopyridine alkaloid, 16-carbomethoxynaufoline.[Pubmed:
12576667]
METHODS AND RESULTS:
Three monoterpenoid gluco-indole alkaloids, 3beta-isodihydrocadambine, cadambine, and 3alpha-dihydrocadambine, were isolated from Nauclea cadamba ROXB. growing in Thailand. The stereochemistry at C19 in 3beta-isodihydrocadambine was elucidated to be R by spectroscopic analysis.
CONCLUSIONS:
Treatment of 3alpha-dihydrocadambine with beta-glucosidase in aqueous ammonium acetate solution gave an indolopyridine alkaloid, 16-carbomethoxynaufoline, and an unusually rearranged compound.
