Gossypin
Catalog No: CFN91987
Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role in the suppression of inflammation, carcinogenesis, and angiogenesis. Gossypin is a new hypocholesterolemic agent that up-regulates LDLR expression independent of SREBP-2 but is dependent on ERK activation. Gossypin has ameliorative effect against gentamicin-induced nephrotoxicity in rats. Gossypin also shows inhibitory effects on RANKL-induced osteoclast differentiation and bone resorption in murine macrophages (LB364).