Fuziline
Fuziline shows significant insecticidal activity against Nilaparvata legen and Aphis medicagini. Fuziline shows activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Phytother Res.2022, 10.1002:ptr.7626.
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Front Nutr.2023, 10:1168095.
Microchemical Journal2023, 194:109249
Environ Toxicol.2019, 34(4):513-520.
Antioxidants (Basel).2023, 12(1):189.
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Molecules, 2012, 17(8):9939-46.
Alkaloids isolated from the lateral root of Aconitum carmichaelii.[Pubmed:
22907155 ]
Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: Fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7).
METHODS AND RESULTS:
Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.
《Pharmacy and Clinics of Chinese Materia Medica》 2014-03
The pharmacological research progress of Fuziline and Neoline[Reference:
WebLink]
By analyzing and summarizing pharmacological research literature about Fuziline and Neoline,the pharmacological research of both drugs are found to be mainly concentrated on the cardiovascular system,analgesia,anesthesia,antitumor,insecticidal,and so on.At the same time,Fuziline and Neoline are lack of a comprehensive and systematic pharmacological research.
Biomed Chromatogr. 2014 Dec;28(12):1707-13.
Development and validation of a UHPLC-qTOF-MS method for quantification of fuziline in rat plasma and its application in a pharmacokinetic study.[Pubmed:
24782408]
METHODS AND RESULTS:
A specific and sensitive UHPLC-qTOF-MS method was developed and validated for quantification of Fuziline in rat plasma after oral administration of three dosages. The analyte was separated on an Acquity UPLC BEH C18 column with a total running time of 3 min using a mobile phase of 0.1% formic acid aqueous solution and methanol (80:20, v/v) at a flow-rate of 0.25 mL/min. The calibration curves for Fuziline showed good linearity in the concentrations ranging from 1 to 200 ng/mL with correlation coefficients >0.997. The precision, accuracy, recovery and stability were deemed acceptable. The method was applied to a pharmacokinetics study of Fuziline in rats. The mean half-life was 5.93, 6.13 and 5.12 h for 1, 2 and 4 mg/kg oral administration of Fuziline, respectively. The peak concentration and area under the concentration-time curve increased linearly with the doses.
CONCLUSIONS:
The sum of these results indicated that, in the range of the doses examined, the pharmacokinetics of Fuziline in rat was based on first-order kinetics.
