Diammonium glycyrrhizinate
Catalog No: CFN96843
Diammonium glycyrrhizinate shows antiviral, and anti-inflammatory effects, it can reduce inflammatory injury in a rat model of ulcerative colitis, this may occur via suppression of NF-kappaB, TNF-alpha and ICAM-1 in colonic mucosa. Diammonium glycyrrhizinate may possibly protect the liver from injury via two pathways: direct protection of hepatocytes from apoptosis through an IL-6-dependent way and indirect inhibition of T-cell-mediated inflammation through an IL-10-dependent way.
Diammonium glycyrrhizinate exerts potential beneficial effects on Alzheimer's disease, it can attenuate Aβ(1-42)-induced neuronal injury by preventing mitochondrial dysfunction and oxidative stress and improve cognitive impairment in Aβ(1-42)-induced AD mice.
Diammonium glycyrrhizinate also can inhibit airway smooth muscle proliferation possibly through up- regulation of PPARγ in a murine model of chronic asthma.