Hot Products

Delta-9-Tetrahydrocannabinol
Catalog No: CFN91898

Delta 9-tetrahydrocannabinol(THC) induces dopamine release in the human striatum, this allows new directions in research on the effects of THC in neuropsychiatric disorders, such as schizophrenia. THC demonstrates an analgesic effect in patients experiencing cancer pain, it has antiemetic effect in patients receiving cancer chemotherapy. THC shows neuroprotection against ouabain-induced in vivo excitotoxicity, it promotes tumor growth by inhibiting antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway.

Delta-9-Tetrahydrocannabinolic acid
Catalog No: CFN91872

Delta-9-Tetrahydrocannabinolic acid can protect dopaminergic neurons against MPP(+) induced cell death.

Delta-Tocotrienol
Catalog No: CFN96406

Delta-tocotrienol is a potential angiogenic inhibitor, it (2.5-5 microM) can significantly suppress human colorectal adenocarcinoma cells (DLD-1-CM) -induced tube formation, migration, and adhesion on human umbilical vein endothelial cells.It is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSCLC) cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents. Delta-tocotrienol displays significant radioprotective effects, it protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling.

Deltonin
Catalog No: CFN93052

Deltonin may be a potential chemotherapeutic agent against neck squamous cell carcinoma (HNSCC), it can induce both apoptosis and autophagy in head and neck squamous carcinoma FaDu cell; it also induces apoptosis in MDA-MB-231 human breast cancer cells via reactive oxygen species-mediated mitochondrial dysfunction and ERK/AKT signaling pathways. Deltonin inhibits angiogenesis by regulating VEGFR2 and subsequent signaling pathways in endothelial cells.Deltonin also exhibits induction effect on platelet aggregation.

Demethoxycurcumin
Catalog No: CFN99185

Demethoxycurcumin is a potential additive natural product in combination with chemotherapeutic agents in drug-resistant cancers, which has anti-acanthamoebic, anti-proliferative, antimetastatic, anti-inflammatory, antioxidant activities. It inhibited P-glycoprotein-mediated ATP hydrolysis under concentrations of <1 μM and efficiently inhibited 200 μM verapamil-stimulated ATPase activity.

Demethoxyfumitremorgin C
Catalog No: CFN96937

Demethoxyfumitremorgin C and tryprostatin B are fungal inhibitors of mammalian cell cycle progression at the G(2)/M transition. Demethoxyfumitremorgin C inhibits the proliferation of PC3 human prostate cancer cells via the intrinsic (mitochondrial) and extrinsic pathway, followed by downstream events leading to apoptotic cell death, it could therefore, serve as a useful agent to treat human advanced prostate cancer.

Demethyl tetrandrine
Catalog No: CFN90482

Demethyl tetrandrine and tetrandrine show inhibition on DNA synthesis, the 50% inhibition doses ( ID50 ) are in L7712 and Sl80 cells are 27.5, 24.5 mg/L and 2.6, 3 .5mg/ L , respectively.

Demethyleneberberine
Catalog No: CFN90696

Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1, hypoxia inducible factor α, and inducible nitric oxide synthase, which contributes to oxidative stress and restored sirtuin 1/AMP-activated protein kinase/peroxisome proliferator-activated receptor-γ coactivator-1α pathway-associated fatty acid oxidation in chronic ethanol-fed mice.

Demethylsuberosin
Catalog No: CFN96241

Demethylsuberosin has potential anti-inflammatory activity, it displays suppressive effects on LPS-induced NO and PGE2 production with the IC50 value of 9.42 uM.

Demethylvestitol
Catalog No: CFN96183

Demethylvestitol is a natural product from Spatholobus suberectus.