Daidzin 6''-O-malonate

Daidzin 6''-O-malonate
Product Name Daidzin 6''-O-malonate
CAS No.: 124590-31-4
Catalog No.: CFN91028
Molecular Formula: C24H22O12
Molecular Weight: 502.42 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Targets: ROS | Nrf2 | HO-1 | SOD | Autophagy
Source: The roots of Pueraria lobata
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $388/5mg
Daidzin 6''-O-malonate may have anticancer activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • Saudi Pharm J.2019, 27(1):145-153
  • Phytother Res.2019, 10.1002
  • J Ethnopharmacol.2017, 206:327-336
  • Phytother Res.2020, 34(4):788-795.
  • Fitoterapia.2015, 100:179-86
  • Pak J Pharm Sci.2019, 32(6)
  • J Cell Physiol.2020, 10.1002
  • Appl Biochem Biotechnol.2020, 190(2):732-744
  • J Formos Med Assoc.2020, S0929-6646(20)30425-3
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